A Fuzzy Inference System for Closed-Loop Deep Brain Stimulation in Parkinson's Disease

Simple item page
dc.contributor.authorCámara, Carmen
dc.contributor.authorWarwick, Kevin
dc.contributor.authorBruña Fernández, Ricardo
dc.contributor.authorAziz, Tipu
dc.contributor.authordel Pozo, Francisco
dc.contributor.authorMaestu Unturbe, Fernando
dc.date.accessioned2024-02-08T07:53:21Z
dc.date.available2024-02-08T07:53:21Z
dc.date.issued2015-09-18
dc.description.abstractParkinsons disease is a complex neurodegenerative disorder for which patients present many symptoms, tremor being the main one. In advanced stages of the disease, Deep Brain Stimulation is a generalized therapy which can significantly improve the motor symptoms. However despite its beneficial effects on treating the symptomatology, the technique can be improved. One of its main limitations is that the parameters are fixed, and the stimulation is provided uninterruptedly, not taking into account any fluctuation in the patients state. A closed-loop system which provides stimulation by demand would adjust the stimulation to the variations in the state of the patient, stimulating only when it is necessary. It would not only perform a more intelligent stimulation, capable of adapting to the changes in real time, but also extending the devices battery life, thereby avoiding surgical interventions. In this work we design a tool that learns to recognize the principal symptom of Parkinsons disease and particularly the tremor. The goal of the designed system is to detect the moments the patient is suffering from a tremor episode and consequently to decide whether stimulation is needed or not. For that, local field potentials were recorded in the subthalamic nucleus of ten Parkinsonian patients, who were diagnosed with tremor-dominant Parkinsons disease and who underwent surgery for the implantation of a neurostimulator. Electromyographic activity in the forearm was simultaneously recorded, and the relation between both signals was evaluated using two different synchronization measures. The results of evaluating the synchronization indexes on each moment represent the inputs to the designed system. Finally, a fuzzy inference system was applied with the goal of identifying tremor episodes. Results are favourable, reaching accuracies of higher 98.7 % in 70 % of the patients.
dc.description.departmentDepto. de Psicología Experimental, Procesos Cognitivos y Logopedia
dc.description.departmentDepto. de Radiología, Rehabilitación y Fisioterapia
dc.description.facultyFac. de Psicología
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipCentro de Investigación Biomédica en Red
dc.description.statuspub
dc.identifier.citationCamara, C., Warwick, K., Bruña, R. et al. A Fuzzy Inference System for Closed-Loop Deep Brain Stimulation in Parkinson’s Disease. J Med Syst 39, 155 (2015). https://doi.org/10.1007/s10916-015-0328-x
dc.identifier.doi10.1007/s10916-015-0328-x
dc.identifier.issn1573-689X
dc.identifier.officialurlhttps://link.springer.com/article/10.1007/s10916-015-0328-x
dc.identifier.pmid26385550
dc.identifier.relatedurlhttps://pubmed.ncbi.nlm.nih.gov/26385550/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/100156
dc.issue.number11
dc.journal.titleJournal of Medical Systems
dc.language.isoeng
dc.page.initial155
dc.publisherSpringer
dc.rights.accessRightsrestricted access
dc.subject.cdu616.858
dc.subject.keywordParkinson’s disease
dc.subject.keywordDeep brain stimulation
dc.subject.keywordFuzzy logic
dc.subject.keywordBicoherence
dc.subject.keywordMutual information
dc.subject.ucmNeurociencias (Medicina)
dc.subject.ucmInformática médica y telemedicina
dc.subject.unesco2490 Neurociencias
dc.titleA Fuzzy Inference System for Closed-Loop Deep Brain Stimulation in Parkinson's Disease
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number39
dspace.entity.typePublication
relation.isAuthorOfPublicationef335315-bb52-49b1-8703-63c7caae45f8
relation.isAuthorOfPublicationafa98131-b2fe-40fd-8f89-f3994d80ab72
relation.isAuthorOfPublication.latestForDiscoveryef335315-bb52-49b1-8703-63c7caae45f8
Download
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Cámara et al. 2015 J. Med. Syst. 39.155.pdf
Size:
1.18 MB
Format:
Adobe Portable Document Format
Download
Collections
Artículos