Tissue proteomics in atherosclerosis: elucidating the molecular mechanisms of cardiovascular diseases

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dc.contributor.authorCuesta, Fernando de la
dc.contributor.authorÁlvarez Llamas, Gloria
dc.contributor.authorGil Dones, Félix
dc.contributor.authorMartin-Rojas, Tatiana
dc.contributor.authorZubiri, Irene
dc.contributor.authorPastor Vargas, Carlos
dc.contributor.authorBarderas, Maria
dc.contributor.authorVivanco Martínez, Fernando
dc.date.accessioned2024-01-22T12:33:16Z
dc.date.available2024-01-22T12:33:16Z
dc.date.issued2009
dc.description.abstractAtherosclerosis is a disease with higher levels of mortality in developed countries. Comprehension of the molecular mechanisms can yield very useful information in clinics for prevention, diagnosis and recovery monitoring. Proteomics represents an ideal methodology for this purpose, as proteins constitute the effectors of the different biological processes running during pathogenesis. To date, studies in atherosclerosis have been mainly focused on the search for plasma biomarkers. However, tissue proteomics allows going deeper into tissue secretomes, arterial layers or particular cells of interest, which, in turn, constitutes a more direct approximation to in vivo operating mechanisms. The aim of this review is to report latest advances in tissue proteomics in atherosclerosis and related diseases (e.g., aortic stenosis and ischemic injury).
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Ciencias Químicas
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia y Educación (España)
dc.description.sponsorshipComunidad de Madrid
dc.description.sponsorshipInstituto de Salud Carlos III
dc.description.statuspub
dc.identifier.citationde la Cuesta F, Alvarez-Llamas G, Gil-Dones F, Martin-Rojas T, Zubiri I, Pastor C, Barderas MG, Vivanco F. Tissue proteomics in atherosclerosis: elucidating the molecular mechanisms of cardiovascular diseases. Expert Rev Proteomics. 2009 Aug;6(4):395-409. doi: 10.1586/epr.09.60. PMID: 19681675.
dc.identifier.doi10.1586/epr.09.60
dc.identifier.essn1744-8387
dc.identifier.issn1478-9450
dc.identifier.officialurlhttps://doi.org/10.1586/epr.09.60
dc.identifier.urihttps://hdl.handle.net/20.500.14352/94376
dc.issue.number4
dc.journal.titleExpert Review of Proteomics
dc.language.isoeng
dc.page.final409
dc.page.initial395
dc.publisherTaylor & Francis
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsmetadata only access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu616.12
dc.subject.ucmSistema cardiovascular
dc.subject.unesco3205.01 Cardiología
dc.titleTissue proteomics in atherosclerosis: elucidating the molecular mechanisms of cardiovascular diseases
dc.typejournal article
dc.volume.number6
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery16e9b128-f6de-4009-817c-53e91375baa3
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