Signs and Symptoms of Dry Eye in Keratoconus Patients: A Pilot Study

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dc.contributor.authorCarracedo Rodríguez, Juan Gonzalo
dc.contributor.authorRecchioni, Alberto
dc.contributor.authorAlejandre Alba, Nicolás
dc.contributor.authorMartín Gil, Alba
dc.contributor.authorCrooke Álvarez, Almudena
dc.contributor.authorJiménez Alfaro-Morote, Ignacio
dc.contributor.authorPintor Just, Jesús Jerónimo
dc.dateReceived 13 December 2013; revised 4 November 2014; accepted 9 November 2014; published online 9 December 2014
dc.date.accessioned2023-06-18T06:56:07Z
dc.date.available2023-06-18T06:56:07Z
dc.date.issued2015-11
dc.descriptionReceived 13 December 2013; revised 4 November 2014; accepted 9 November 2014; published online 9 December 2014
dc.description.abstractPurpose: To compare signs and symptoms of dry eye in keratoconus (KC) patients versus healthy subjects. Methods: A total of 15 KC patients (KC group, n = 15 eyes) and 16 healthy subjects (control group, 16 eyes) were enrolled in this study. The Schirmer I test with no anesthetic, tear break-up time (TBUT), corneal staining characteristics, and ocular surface disease index (OSDI) scores were evaluated for both groups. Impression cytology, combined with/scanning laser confocal microscopy (LCM), was performed to evaluate goblet cell density, mucin cloud height (MCH), and goblet cell layer thickness (CLT). Finally, tear concentrations of di-adenosine tetraphosphate (Ap4A) were assessed. Results were statistically analyzed using Shapiro–Wilk and non-parametric Wilcoxon rank sum tests. Statistical significance was set at p < 0.05. Results: KC patients had lower tear volumes and greater corneal staining than did healthy subjects (p < 0.05). OSDI scores were 44.96 ± 8.65 and 17.78 ± 6.50 for the KC and control groups, respectively (p < 0.05). We found no statistically significant differences in TBUT between groups. Impression cytology revealed lower goblet cell densities in KC group patients versus control group subjects (84.88 ± 32.98 and 128.88 ± 50.60 cells/mm,2 respectively, p < 0.05). There was a statistically significant reduction in MCH and CLT in KC group patients compared with control group subjects. Ap4A tear concentrations were higher in KC group patients than in control group subjects (2.56 ± 1.10 and 0.15 ± 0.12 µM, respectively, p < 0.05). Conclusions: The parameters evaluated in this study indicate that KC patients suffer greater symptoms of dry eye and greater tear instability, primarily due to the decreased mucin production in their tears, than do healthy patients with no KC.en
dc.description.departmentDepto. de Optometría y Visión
dc.description.departmentUnidad Docente de Bioquímica y Biología Molecular
dc.description.facultyFac. de Óptica y Optometría
dc.description.refereedTRUE
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/39196
dc.identifier.citationCarracedo Rodríguez, J. G., Recchioni, A., Alejandre Alba, N. et al. «Signs and Symptoms of Dry Eye in Keratoconus Patients: A Pilot Study». Current Eye Research, vol. 40, n.o 11, noviembre de 2015, pp. 1088-94. DOI.org (Crossref), https://doi.org/10.3109/02713683.2014.987871.
dc.identifier.doi10.3109/02713683.2014.987871
dc.identifier.issn0271-3683
dc.identifier.officialurlhttp://dx.doi.org/10.3109/02713683.2014.987871
dc.identifier.relatedurlhttp://www.tandfonline.com/doi/full/10.3109/02713683.2014.987871
dc.identifier.urihttps://hdl.handle.net/20.500.14352/24620
dc.issue.number11
dc.journal.titleCurrent Eye Research
dc.language.isoeng
dc.page.final1094
dc.page.initial1088
dc.publisherTaylor & Francis
dc.rights.accessRightsrestricted access
dc.subject.cdu617.713
dc.subject.cdu617.764
dc.subject.keyword3D impression cytology
dc.subject.keywordDinucleotide
dc.subject.keywordDry eye
dc.subject.keywordKeratoconus
dc.subject.ucmBioquímica (Química)
dc.subject.ucmOftalmología
dc.subject.ucmOptometría
dc.subject.unesco3201.09 Oftalmología
dc.subject.unesco2209.15 Optometría
dc.titleSigns and Symptoms of Dry Eye in Keratoconus Patients: A Pilot Studyen
dc.typejournal article
dc.volume.number40
dspace.entity.typePublication
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