Induction of the Mitochondrial NDUFA4L2 Protein by HIF-1α Decreases Oxygen Consumption by Inhibiting Complex I Activity

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dc.contributor.authorTello, Daniel
dc.contributor.authorBalsa, Eduardo
dc.contributor.authorAcosta-Iborra, Bárbara
dc.contributor.authorFuertes-Yebra, Esther
dc.contributor.authorElorza, Ainara
dc.contributor.authorOrdóñez, Ángel
dc.contributor.authorCorral-Escariz, María
dc.contributor.authorSoro, Inés
dc.contributor.authorLópez-Bernardo, Elia
dc.contributor.authorPerales-Clemente, Ester
dc.contributor.authorMartínez Ruiz, Antonio
dc.contributor.authorEnríquez, José Antonio
dc.contributor.authorAragonés, Julián
dc.contributor.authorCadenas, Susana
dc.contributor.authorLandázuri, Manuel O.
dc.date.accessioned2024-05-21T15:03:43Z
dc.date.available2024-05-21T15:03:43Z
dc.date.issued2011-12-07
dc.description.abstractThe fine regulation of mitochondrial function has proved to be an essential metabolic adaptation to fluctuations in oxygen availability. During hypoxia, cells activate an anaerobic switch that favors glycolysis and attenuates the mitochondrial activity. This switch involves the hypoxia-inducible transcription factor-1 (HIF-1). We have identified a HIF-1 target gene, the mitochondrial NDUFA4L2 (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex, 4-like 2). Our results, obtained employing NDUFA4L2-silenced cells and NDUFA4L2 knockout murine embryonic fibroblasts, indicate that hypoxiainduced NDUFA4L2 attenuates mitochondrial oxygen consumption involving inhibition of Complex I activity, which limits the intracellular ROS production under low-oxygen conditions. Thus, reducing mitochondrial Complex I activity via NDUFA4L2 appears to be an essential element in the mitochondrial reprogramming induced by HIF-1.
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia e Innovación
dc.description.sponsorshipComunidad Auto´ noma de Madrid (SAL 2006/ 0311), Metoxia Project-Health (F2 2009-222741), and Recava Network (RD 06/0014/0031) to M.O.L.; PS09/00101 and CP07/00143 to A.M.-R.; PI060701, PS09/00116, and CP08/00204 to S.C.; BFU2008-03407/BMC to J.A.; SAF2009-08007 to J.A.E.; and CSD2007-00020
dc.description.statuspub
dc.identifier.doi10.1016/j.cmet.2011.10.008
dc.identifier.issn1550-4131
dc.identifier.urihttps://hdl.handle.net/20.500.14352/104286
dc.issue.number14
dc.journal.titleCell Metabolism
dc.language.isoeng
dc.page.final779
dc.page.initial768
dc.relation.projectIDinfo:eu-repo/grantAgreement/MEC//CSD2007-00020/ES/Papel funcional del estrés oxidativo y nitrosativo en grandes sistemas biológicos/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN//SAF 2007-06592
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN//SAF 2010-14851
dc.relation.projectIDSAL 2006/ 0311
dc.relation.projectIDF2 2009-222741
dc.relation.projectIDRD 06/0014/0031
dc.relation.projectIDF2 2009-222741
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN//PS09%2F00116/ES/DESACOPLAMIENTO MITOCONDRIAL EN ISQUEMIA EXPERIMENTAL Y CLINICA/
dc.relation.projectIDPI060701
dc.relation.projectIDinfo:eu-repo/grantAgreement/MSC//CP07%2F00143/ES/CP07%2F00143/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN//PS09%2F00101/ES/PAPEL DE LAS ESPECIES REACTIVAS DE OXIGENO Y NITROGENO Y DE LAS MODIFICACIONES OXIDATIVAS DE PROTEINAS EN LA RESPUESTA A HIPOXIA EN FISIOPATOLOGIA CARDIOVASCULAR/
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu577.1
dc.subject.cdu577.2
dc.subject.ucmBioquímica (Farmacia)
dc.subject.ucmBiología molecular (Farmacia)
dc.subject.unesco2302 Bioquímica
dc.titleInduction of the Mitochondrial NDUFA4L2 Protein by HIF-1α Decreases Oxygen Consumption by Inhibiting Complex I Activity
dc.typejournal article
dc.type.hasVersionVoR
dspace.entity.typePublication
relation.isAuthorOfPublicationeec0b303-34c9-47dd-9ec6-704b6c6c7acd
relation.isAuthorOfPublication.latestForDiscoveryeec0b303-34c9-47dd-9ec6-704b6c6c7acd
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