Impaired Mesopic Visual Acuity in Eyes with Early Age-Related Macular Degeneration

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dc.contributor.authorPuell Marín, María Cinta
dc.contributor.authorBarrio De Santos, Ana Rosa
dc.contributor.authorPalomo Álvarez, Catalina
dc.contributor.authorGómez Sanz, Fernando J.
dc.contributor.authorClement Corral, Amaya
dc.contributor.authorPérez Carrasco, María Jesús
dc.date.accessioned2023-06-20T04:21:42Z
dc.date.available2023-06-20T04:21:42Z
dc.date.issued2012
dc.descriptionAbierto en la web del editor
dc.description.abstractPurpose.: To determine photopic and mesopic distance high-contrast visual acuity (HC-VA) and low-contrast visual acuity (LC-VA) in eyes with early age-related macular degeneration (AMD). Methods.: Measurements were made in 22 subjects with early AMD and 28 healthy control subjects. Inclusion criteria included a photopic HC-VA of 20/25 or better. Distance VA was measured using HC (96%) and LC (10%) Bailey-Lovie logMAR letter charts under photopic (85 cd/m2) and mesopic (0.1–0.2 cd/m2) luminance conditions. Results.: Mean mesopic distance HC-VA and LC-VA were significantly worse (0.1 logMAR and 0.28 logMAR, respectively) in the early AMD group than in the control group. Under mesopic conditions, the mean difference between LC-VA and HC-VA was significantly greater in the early AMD (0.45 logMAR) than the control group (0.27 logMAR). Mean differences between mesopic versus photopic HC-VA and mesopic versus photopic LC-VA were significantly greater in the early AMD than the control group (0.13 and 0.32 logMAR of difference between the means, respectively). Sensitivity and specificity were significantly greater for mesopic LC-VA than for mesopic HC-VA (Receiver Operating Characteristics, area under the curve [AUC], 0.94 ± 0.030 and 0.76 ± 0.067, respectively). AUC values for photopic HC-VA and LC-VA were below 0.70. Conclusions.: Visual acuity testing under low luminance conditions emerged as an optimal quantitative measure of retinal function in early AMD.en
dc.description.departmentDepto. de Optometría y Visión
dc.description.facultyFac. de Óptica y Optometría
dc.description.refereedTRUE
dc.description.sponsorshipFundación Investigación Médica Mutua Madrileña
dc.description.sponsorshipBanco Santander-Universidad Complutense de Madrid
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/39858
dc.identifier.citationPuell Marín, M. C., Barrio De Santos, A. R., Palomo Álvarez, C. et al. «Impaired Mesopic Visual Acuity in Eyes with Early Age-Related Macular Degeneration». Investigative Opthalmology & Visual Science, vol. 53, n.o 11, octubre de 2012, p. 7310. DOI.org (Crossref), https://doi.org/10.1167/iovs.11-8649.
dc.identifier.doi10.1167/iovs.11-8649
dc.identifier.issn0146-0404
dc.identifier.officialurlhttps//doi.org/10.1167/iovs.11-8649
dc.identifier.relatedurlhttp://iovs.arvojournals.org/article.aspx?articleid=2127992
dc.identifier.urihttps://hdl.handle.net/20.500.14352/45208
dc.issue.number11
dc.journal.titleInvestigative Ophthalmology and Visual Science
dc.language.isoeng
dc.page.final7314
dc.page.initial7310
dc.publisherThe Association for Research in Vision and Ophthalmology, Inc.
dc.relation.projectIDFMM-02538/2008
dc.relation.projectIDGR 58/08
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject.cdu617.7
dc.subject.cdu617.75
dc.subject.keywordMediated multifocal electroretinogram
dc.subject.keywordGeographic Atrphy
dc.subject.keywordDark-Adaptation
dc.subject.keywordMaculopathy
dc.subject.keywordVision
dc.subject.keywordContrast
dc.subject.keywordLuminance
dc.subject.keywordChart
dc.subject.keywordClassification
dc.subject.keywordDysfunction
dc.subject.ucmOftalmología
dc.subject.ucmOptometría
dc.subject.unesco3201.09 Oftalmología
dc.subject.unesco2209.15 Optometría
dc.titleImpaired Mesopic Visual Acuity in Eyes with Early Age-Related Macular Degenerationen
dc.typejournal article
dc.volume.number53
dspace.entity.typePublication
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