Dapivirine Bioadhesive Vaginal Tablets Based on Natural Polymers for the Prevention of Sexual Transmission of HIV

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dc.contributor.authorCazorla Luna, Raúl
dc.contributor.authorMartín Illana, Araceli
dc.contributor.authorNotario Pérez, Fernando
dc.contributor.authorBedoya Del Olmo, Luis Miguel
dc.contributor.authorRuiz Caro, Roberto
dc.contributor.authorBermejo Benito, Paulina
dc.contributor.authorVeiga Ochoa, María Dolores
dc.date.accessioned2023-06-17T12:40:45Z
dc.date.available2023-06-17T12:40:45Z
dc.date.issued2019-03-13
dc.description.abstractYoung sub-Saharan women are a group that is vulnerable to the sexual transmission of HIV. Pre-exposure prophylaxis through vaginal microbicides could provide them an option for self-protection. Dapivirine has been demonstrated to have topical inhibitory effects in HIV, and to provide protection against the sexual transmission of this virus. This paper reports on the studies into swelling behaviour, bioadhesion and release carried out on dapivirine tablets based on chitosan, locust bean gum and pectin, to select the most suitable formulation. The modified simulated vaginal fluid led to a high solubility of dapivirine and allowed the dapivirine release profiles to be characterized in sink conditions; this aqueous medium is an alternative to organic solvents, which are not a realistic option when evaluating systems whose behaviour varies in aqueous and organic media. Of the formulations evaluated, dapivirine/pectin tablets containing 290 mg of polymer and 30 mg of dapivirine present the most moderate swelling, making them the most comfortable dosage forms. Their high bioadhesive capacity would also allow the formulation to remain in the action zone and release the drug in a sustained manner, pointing to this formulation as the most promising candidate for future evaluations of vaginal microbicides for the prevention of HIV.en
dc.description.departmentDepto. de Farmacia Galénica y Tecnología Alimentaria
dc.description.departmentDepto. de Farmacología, Farmacognosia y Botánica
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía, Comercio y Empresa (España)/Fondo Europeo de Desarrollo Regional
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/70298
dc.identifier.citationCazorla Luna, R., Martín Illana, A., Notario Pérez, F. et al. «Dapivirine Bioadhesive Vaginal Tablets Based on Natural Polymers for the Prevention of Sexual Transmission of HIV». Polymers, vol. 11, n.o 3, marzo de 2019, p. 483. DOI.org (Crossref), https://doi.org/10.3390/polym11030483.
dc.identifier.doi10.3390/polym11030483
dc.identifier.issn2073-4360
dc.identifier.officialurlhttps://doi.org/10.3390/polym11030483
dc.identifier.urihttps://hdl.handle.net/20.500.14352/12762
dc.issue.number3
dc.journal.titlePolymers
dc.language.isospa
dc.page.initial483
dc.publisherMDPI
dc.relation.projectIDMAT2012-34552; MAT2012-34552
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.cdu615.4
dc.subject.keywordHIV vaginal preexposure prophylaxis
dc.subject.keywordDapivirine controlled release
dc.subject.keywordBioadhesive vaginal tablets
dc.subject.keywordPectin
dc.subject.keywordLocust bean gum
dc.subject.keywordChitosan
dc.subject.ucmEnfermedades infecciosas
dc.subject.ucmFarmacología (Farmacia)
dc.subject.ucmTecnología farmaceútica
dc.subject.unesco3205.05 Enfermedades Infecciosas
dc.subject.unesco3209 Farmacología
dc.titleDapivirine Bioadhesive Vaginal Tablets Based on Natural Polymers for the Prevention of Sexual Transmission of HIVen
dc.typejournal article
dc.volume.number11
dspace.entity.typePublication
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