Connections between the internal and the external capsules and the globus pallidus in the sheep: A dichromate stain X‐ray microtomographic study

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dc.contributor.authorMurillo González, Jorge Alfonso
dc.contributor.authorNotario, Belen
dc.contributor.authorMaldonado Bautista, Estela
dc.contributor.authorMartínez Sanz, Elena
dc.contributor.authorBarrio Asensio, María Del Carmen
dc.contributor.authorHerrera Lara, Manuel Eugenio
dc.date.accessioned2024-04-02T11:17:20Z
dc.date.available2024-04-02T11:17:20Z
dc.date.issued2020-08-13
dc.description.abstractSheep are recognized as useful species for translational neurodegeneration research, in particular for the study of Huntington disease. There is a lack of information regarding the detailed anatomy and connections of the basal ganglia of sheep, in normal myeloarchitectonics and in tract-tracing studies. In this work, the organization of the corticostriatal projections at the level of the putamen and globus pallidus (GP) are explored. For the first time, the myeloarchitectonic pattern of connections between the internal (IC) and the external (EC) capsules with the GP have been investigated in the sheep. Formaldehyde-fixed blocks of the striatum were treated with a metallic stain containing potassium dichromate and visualized using micro-CT (µ-CT). The trivalent chromium (Cr3+), attached to myelin phospholipids, imparts a differential contrast to the grey and white matter compartments, which allows the visualization of myelinated fascicles in µ-CT images. The fascicles were classified according to their topographical location in dorsal supreme fascicles (X, Y, apex) arising from the IC and EC; pre-commissurally, basal fascicles connecting the ventral part of the EC with the lateral zone of the ventral pallidum (VP) and, post-commissurally, superior (Z1 ), middle (Z2 ) and lower (Z3 ) fascicles, connecting at different levels the EC with the GP. The results suggest that the presumptive cortical efferent and afferent fibres to the pallidum could be organized according to a dorsal to ventrolateral topography in the sheep, similar to that seen in other mammals. The proposed methodology has the potential to delineate the myeloarchitectonic patterns of nervous systems and tracts.
dc.description.departmentDepto. de Anatomía y Embriología
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationMurillo-González JA, Notario B, Maldonado E, Martinez-Sanz E, Barrio MC, Herrera M. Connections between the internal and the external capsules and the globus pallidus in the sheep: A dichromate stain X-ray microtomographic study. Anat Histol Embryol. 2021 Jan;50(1):84-92.
dc.identifier.doi10.1111/ahe.12604
dc.identifier.issn0340-2096
dc.identifier.issn1439-0264
dc.identifier.officialurlhttps://onlinelibrary.wiley.com/doi/10.1111/ahe.12604
dc.identifier.pmid32794251
dc.identifier.relatedurlhttps://pubmed.ncbi.nlm.nih.gov/32794251/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/102502
dc.issue.number1
dc.journal.titleAnatomia Histologia Embryologia
dc.language.isoeng
dc.page.final92
dc.page.initial84
dc.publisherWILEY
dc.rights.accessRightsrestricted access
dc.subject.cdu611
dc.subject.keywordX-ray microcomputed tomography
dc.subject.keywordBasal ganglia
dc.subject.keywordExternal capsule
dc.subject.keywordInternal capsule
dc.subject.keywordPutamen
dc.subject.keywordSheep
dc.subject.ucmCiencias Biomédicas
dc.subject.unesco32 Ciencias Médicas
dc.titleConnections between the internal and the external capsules and the globus pallidus in the sheep: A dichromate stain X‐ray microtomographic study
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number50
dspace.entity.typePublication
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