Connections between the internal and the external capsules and the globus pallidus in the sheep: A dichromate stain X‐ray microtomographic study
dc.contributor.author | Murillo González, Jorge Alfonso | |
dc.contributor.author | Notario, Belen | |
dc.contributor.author | Maldonado Bautista, Estela | |
dc.contributor.author | Martínez Sanz, Elena | |
dc.contributor.author | Barrio Asensio, María Del Carmen | |
dc.contributor.author | Herrera Lara, Manuel Eugenio | |
dc.date.accessioned | 2024-04-02T11:17:20Z | |
dc.date.available | 2024-04-02T11:17:20Z | |
dc.date.issued | 2020-08-13 | |
dc.description.abstract | Sheep are recognized as useful species for translational neurodegeneration research, in particular for the study of Huntington disease. There is a lack of information regarding the detailed anatomy and connections of the basal ganglia of sheep, in normal myeloarchitectonics and in tract-tracing studies. In this work, the organization of the corticostriatal projections at the level of the putamen and globus pallidus (GP) are explored. For the first time, the myeloarchitectonic pattern of connections between the internal (IC) and the external (EC) capsules with the GP have been investigated in the sheep. Formaldehyde-fixed blocks of the striatum were treated with a metallic stain containing potassium dichromate and visualized using micro-CT (µ-CT). The trivalent chromium (Cr3+), attached to myelin phospholipids, imparts a differential contrast to the grey and white matter compartments, which allows the visualization of myelinated fascicles in µ-CT images. The fascicles were classified according to their topographical location in dorsal supreme fascicles (X, Y, apex) arising from the IC and EC; pre-commissurally, basal fascicles connecting the ventral part of the EC with the lateral zone of the ventral pallidum (VP) and, post-commissurally, superior (Z1 ), middle (Z2 ) and lower (Z3 ) fascicles, connecting at different levels the EC with the GP. The results suggest that the presumptive cortical efferent and afferent fibres to the pallidum could be organized according to a dorsal to ventrolateral topography in the sheep, similar to that seen in other mammals. The proposed methodology has the potential to delineate the myeloarchitectonic patterns of nervous systems and tracts. | |
dc.description.department | Depto. de Anatomía y Embriología | |
dc.description.faculty | Fac. de Medicina | |
dc.description.refereed | TRUE | |
dc.description.status | pub | |
dc.identifier.citation | Murillo-González JA, Notario B, Maldonado E, Martinez-Sanz E, Barrio MC, Herrera M. Connections between the internal and the external capsules and the globus pallidus in the sheep: A dichromate stain X-ray microtomographic study. Anat Histol Embryol. 2021 Jan;50(1):84-92. | |
dc.identifier.doi | 10.1111/ahe.12604 | |
dc.identifier.issn | 0340-2096 | |
dc.identifier.issn | 1439-0264 | |
dc.identifier.officialurl | https://onlinelibrary.wiley.com/doi/10.1111/ahe.12604 | |
dc.identifier.pmid | 32794251 | |
dc.identifier.relatedurl | https://pubmed.ncbi.nlm.nih.gov/32794251/ | |
dc.identifier.uri | https://hdl.handle.net/20.500.14352/102502 | |
dc.issue.number | 1 | |
dc.journal.title | Anatomia Histologia Embryologia | |
dc.language.iso | eng | |
dc.page.final | 92 | |
dc.page.initial | 84 | |
dc.publisher | WILEY | |
dc.rights.accessRights | restricted access | |
dc.subject.cdu | 611 | |
dc.subject.keyword | X-ray microcomputed tomography | |
dc.subject.keyword | Basal ganglia | |
dc.subject.keyword | External capsule | |
dc.subject.keyword | Internal capsule | |
dc.subject.keyword | Putamen | |
dc.subject.keyword | Sheep | |
dc.subject.ucm | Ciencias Biomédicas | |
dc.subject.unesco | 32 Ciencias Médicas | |
dc.title | Connections between the internal and the external capsules and the globus pallidus in the sheep: A dichromate stain X‐ray microtomographic study | |
dc.type | journal article | |
dc.type.hasVersion | VoR | |
dc.volume.number | 50 | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 7a351e41-71e3-4b0e-b130-49213b6b3d50 | |
relation.isAuthorOfPublication | 1c053b34-9bf5-446b-ba75-0444f6aecfb6 | |
relation.isAuthorOfPublication | 5f07d36a-b597-4586-ba12-ab550b70466f | |
relation.isAuthorOfPublication | fc5b5960-fd50-4dfd-8a3c-70516122d687 | |
relation.isAuthorOfPublication | 670d850e-bac7-4675-a37b-1fb59aba8e56 | |
relation.isAuthorOfPublication.latestForDiscovery | 7a351e41-71e3-4b0e-b130-49213b6b3d50 |
Download
Original bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- Murillo-Gonzalez et al (2020).pdf
- Size:
- 1.23 MB
- Format:
- Adobe Portable Document Format