Data: Ciprofloxacin Release and Corrosion Behaviour of a Hybrid PEO/PCL Coating on Mg3Zn0.4Ca Alloy
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2023
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MDPI
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Abstract
In the present work, a hybrid hierarchical coating (HHC) system comprising a plasma electrolytic oxidation (PEO) coating and a homogeneously porous structured polycaprolactone (PCL) top-coat layer, loaded with ciprofloxacin (CIP), was developed on Mg3Zn0.4Ca alloy. According to the findings, the HHC system avoided burst release and ensured gradual drug elution (64% over 240 h). The multi-level protection of the magnesium alloy is achieved through sealing of the PEO coating pores by the polymer layer and the inhibiting effect of CIP (up to 74%). The corrosion inhibition effect of HHC and the eluted drug is associated with the formation of insoluble CIP-Me (Mg/Ca) chelates that repair the defects in the HHC and impede the access of corrosive species as corroborated by FTIR spectra, EIS and SEM images after 24 h of immersion. Therefore, CIP participates in an active protection mechanism by interacting with cations coming through the damaged coating.
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Data for paper entitled, “Ciprofloxacin release and corrosion behaviour of a hybrid PEO/PCL coating on Mg3Zn0.4Ca alloy” including:
- Processed Data: Ciprofloxacin release after 240h of immersion from PCL film and multi layer system , Hydrogen evolution curves vs time after 13 days, FTIR spectra of PCL, CIP and PCL+CIP; Modulus of impedance at low frequencies and pH evolution for multilayer system with and without ciprofloxacin 48h of immersion, Resistance of multilayer system with and without ciprofloxacin 2 and 24h of immersion by EIS, Local EDS analysis (at. %) of multilayer system with and without ciprofloxacin after 24 h of immersion in EIS
- Processed Images: SEM images of polymer coatings with and without ciprofloxacin, ciprofloxacin release from PCL films and multilayer system, H2 evolution test for multilayer system with and without ciprofloxacin, SEM images of multilayer system with ciprofloxacin after 24 h of immersion, TEM images from PEO coating, Optical micrographs and SVET current density distribution on CIP-free and CIP-loaded HCC system, Local pH distribution and local dissolved H2 concentration for multilayer system with and without ciprofloxacin after 1 h, 6 h and 24 h of immersion, Regulation of pH by CIP zwitterion release, SEM images of multilayer system with ciprofloxacin after local measurements, FTIR spectra, Modulus of impedance at low frequencies and pH evolution for multilayer system with and without ciprofloxacin 48h of immersion, SEM images of multilayer system with and without ciprofloxacin after 24 h of immersion by EIS,
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