Comparison of periodontal ligament and gingiva-derived mesenchymal stem cells for regenerative therapies.

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dc.contributor.authorSantamaría S
dc.contributor.authorSanchez N
dc.contributor.authorSanz Alonso, Mariano
dc.contributor.authorGarcia-Sanz JA
dc.date.accessioned2024-02-09T12:09:29Z
dc.date.available2024-02-09T12:09:29Z
dc.date.issued2017-05
dc.description.abstractObjectives: Tissue-engineering therapies using undifferentiated mesenchymal cells (MSCs) from intra-oral origin have been tested in experimental animals. This experimental study compared the characteristics of undifferentiated mesenchymal stem cells from either periodontal ligament or gingival origin, aiming to establish the basis for the future use of these cells on regenerative therapies. Materials and methods: Gingiva-derived mesenchymal stem cells (GMSCs) were obtained from de-epithelialized gingival biopsies, enzymatically digested and expanded in conditions of exponential growth. Their growth characteristics, phenotype, and differentiation ability were compared with those of periodontal ligament-derived mesenchymal stem cells (PDLMSCs). Results: Both periodontal ligament- and gingiva-derived cells displayed a MSC-like phenotype and were able to differentiate into osteoblasts, chondroblasts, and adipocytes. These cells were genetically stable following in vitro expansion and did not generate tumors when implanted in immunocompromised mice. Furthermore, under suboptimal growth conditions, GMSCs proliferated with higher rates than PDLMSCs. Conclusions: Stem cells derived from gingival biopsies represent bona fide MSCs and have demonstrated genetic stability and lack of tumorigenicity. Clinical relevance: Gingiva-derived MSCs may represent an accessible source of messenchymal stem cells to be used in future periodontal regenerative therapies.
dc.description.departmentDepto. de Especialidades Clínicas Odontológicas
dc.description.facultyFac. de Odontología
dc.description.refereedTRUE
dc.description.sponsorshipProyecto EC10-095 financiado por el Ministerio de Sanidad
dc.description.statuspub
dc.identifier.citationSantamaría S, Sanchez N, Sanz M, Garcia-Sanz JA. Comparison of periodontal ligament and gingiva-derived mesenchymal stem cells for regenerative therapies. Clin Oral Investig. 2017 May;21(4):1095-1102. doi: 10.1007/s00784-016-1867-3.
dc.identifier.doi10.1007/s00784-016-1867-3.
dc.identifier.officialurlhttps://link.springer.com/article/10.1007/s00784-016-1867-3
dc.identifier.urihttps://hdl.handle.net/20.500.14352/100897
dc.issue.number4
dc.journal.titleClin Oral Investig.
dc.language.isoeng
dc.relation.projectIDProyecto EC10-095 financiado por el Ministerio de Sanidad
dc.rights.accessRightsrestricted access
dc.subject.cdu616.314.17-008.1
dc.subject.keywordGingival
dc.subject.keywordMesenchymal stem cells
dc.subject.keywordPeriodontal ligament
dc.subject.keywordPeriodontal regeneration
dc.subject.keywordTissue engineering
dc.subject.ucmOdontología (Odontología)
dc.subject.ucmPeriodoncia
dc.subject.unesco32 Ciencias Médicas
dc.titleComparison of periodontal ligament and gingiva-derived mesenchymal stem cells for regenerative therapies.
dc.typejournal article
dc.volume.number21
dspace.entity.typePublication
relation.isAuthorOfPublication64cb103c-84c2-43c3-a4fc-60b1e598007d
relation.isAuthorOfPublication.latestForDiscovery64cb103c-84c2-43c3-a4fc-60b1e598007d
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