Long-term effect of intravitreal ranibizumab therapy on retinal nerve fiber layer in eyes with exudative age-related macular degeneration

Simple item page
dc.contributor.authorValverde Megías, Alicia
dc.contributor.authorRuiz Calvo, Aurora
dc.contributor.authorMurciano Cespedosa, Antonio
dc.contributor.authorHernández Ruiz, Samuel
dc.contributor.authorMartínez De La Casa Fernández-Borrella, José María
dc.contributor.authorGarcía Feijoo, Julián
dc.dateReceived: 19 January 2019; Revised: 18 March 2019; Accepted: 11 April 2019; First Online: 03 May 2019
dc.date.accessioned2023-06-17T13:24:28Z
dc.date.available2023-06-17T13:24:28Z
dc.date.issued2019-07
dc.description.abstractPurpose: To investigate long-term effect (96 months) of intravitreal ranibizumab administered for exudative age-related macular degeneration (AMD) on retinal nerve fiber layer (RNFL) thickness when used following a pro re nata regimen. Methods: In this prospective study, 20 eyes of 20 patients diagnosed with exudative AMD were included. Contralateral non-exudative AMD eyes of nine of these patients were included as controls. Data on intraocular pressure (IOP) and number of injections were recorded. Spectralis optic coherence tomography (OCT) of the circumpapillary RNFL was performed under dilation when diagnosis was made and before the three loading injections. “Follow-up” software was selected to accurately compare baseline with subsequent images through the 8 years of the study. Results: Baseline IOP was 14.1 mmHg both in study (standard deviation, SD: 0.8) and control eyes (SD: 0.9) and remained unchanged during the study. Mean number of injections was 21 (SD: 2.8) at the end of the study. Mean average thickness of RNFL in the study eye group at the end of the study was 96.5 μm (SD: 2.1). Mean loss for the study period was 5.3 μm (SD: 0.7; p < 0.0001). Corresponding RNFL values for controls were 92.9 (SD: 3.2) and 5.8 μm (SD: 1.2; p < 0.001). Superior temporal sector had the greatest loss in both groups, followed by inferior and nasal sectors. No statistically significant differences were found when comparing losses in injected eyes versus control eyes. Conclusions: RNFL thickness decreased both equally in injected eyes and control eyes. Thus, no long-term effects of intravitreal ranibizumab were observed on the retinal nerve fiber layer thickness.en
dc.description.departmentUnidad Docente de Inmunología, Oftalmología y ORL
dc.description.facultyFac. de Óptica y Optometría
dc.description.refereedTRUE
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/55736
dc.identifier.citationValverde-Megías, A., Ruiz Calvo, A., Murciano Cespedosa, A. et al. «Long-Term Effect of Intravitreal Ranibizumab Therapy on Retinal Nerve Fiber Layer in Eyes with Exudative Age-Related Macular Degeneration». Graefe’s Archive for Clinical and Experimental Ophthalmology, vol. 257, n.o 7, julio de 2019, pp. 1459-66. DOI.org (Crossref), https://doi.org/10.1007/s00417-019-04325-y.
dc.identifier.doi10.1007/s00417-019-04325-y
dc.identifier.issn0721-832X
dc.identifier.officialurlhttps://doi.org/10.1007/s00417-019-04325-y
dc.identifier.relatedurlhttps://link.springer.com/article/10.1007/s00417-019-04325-y
dc.identifier.urihttps://hdl.handle.net/20.500.14352/13393
dc.issue.number7
dc.journal.titleGraefe's Archive for Clinical and Experimental Ophthalmology
dc.language.isoeng
dc.page.final1466
dc.page.initial1459
dc.publisherSpringer
dc.rights.accessRightsrestricted access
dc.subject.cdu617.731:615.456
dc.subject.cdu617.736-003
dc.subject.keywordNerve fiber layer
dc.subject.keywordAnti-VEGF
dc.subject.keywordOCT
dc.subject.keywordAMD
dc.subject.keywordRanibizumab
dc.subject.ucmFarmacología (Medicina)
dc.subject.ucmOftalmología
dc.subject.ucmAnatomía ocular
dc.subject.unesco3201.09 Oftalmología
dc.titleLong-term effect of intravitreal ranibizumab therapy on retinal nerve fiber layer in eyes with exudative age-related macular degenerationen
dc.typejournal article
dc.volume.number257
dspace.entity.typePublication
relation.isAuthorOfPublication23a67cdf-befc-4140-a656-d25ffbfd5740
relation.isAuthorOfPublicationa08bc152-a727-4918-8e7e-1fab4ad77e8f
relation.isAuthorOfPublication273a99c3-2c9f-4dd0-8939-b7ff3593124c
relation.isAuthorOfPublication558b8023-6d72-4dff-9f99-2e60f6f31843
relation.isAuthorOfPublication.latestForDiscovery23a67cdf-befc-4140-a656-d25ffbfd5740
Download
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Valverde-Megías2019_Article_Long-termEffectOfIntravitrealR.pdf
Size:
2.95 MB
Format:
Adobe Portable Document Format
Download
Collections
Artículos