Expression of glucose transporter isoform GLUT‐2 and glucokinase genes in human brain

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dc.contributor.authorChowen, Julie A.
dc.contributor.authorRábano, Alberto
dc.contributor.authorVázquez Pérz, Patricia
dc.contributor.authorRoncero Rincón, Isabel
dc.contributor.authorÁlvarez García, Elvira
dc.contributor.authorSanz Miguel, María Del Carmen
dc.contributor.authorBlázquez Fernández, Enrique
dc.contributor.editorWiley
dc.date.accessioned2024-01-29T16:09:03Z
dc.date.available2024-01-29T16:09:03Z
dc.date.issued2004-02-04
dc.description.abstractThe glucose transporter isoform-2 (GLUT-2) and glucokinase are considered to be components of a glucose sensor system controlling several key processes, and hence may modulate feeding behaviour. We have found GLUT-2 and glucokinase mRNAs in several brain regions, including the ventromedial and arcuate nuclei of the hypothalamus. GLUT-2, glucokinase and glucokinase regulatory protein mRNAs and proteins were present in these areas as determined by biochemical approaches. In addition, glucose-phosphorylating activity with a high apparent Km for glucose that displayed no product inhibition by glucose-6-phosphate was observed. Increased glycaemia after meals may be recognized by specific hypothalamic neurones due to the high Km of GLUT-2 and glucokinase. This enzyme is considered to be the true glucose sensor because it catalyses the rate-limiting step of glucose catabolism its activity being regulated by interaction with glucokinase regulatory protein, that functions as a metabolic sensor
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationRoncero I, Alvarez E, Chowen JA, et al. Expression of glucose transporter isoform GLUT-2 and glucokinase genes in human brain. J Neurochem. 2004;88(5):1203-1210. doi:10.1046/j.1471-4159.2003.02269.x
dc.identifier.doi10.1046/j.1471-4159.2003.02269.x
dc.identifier.issn0022-3042
dc.identifier.issn1471-4159
dc.identifier.officialurlhttps://onlinelibrary.wiley.com/doi/full/10.1046/j.1471-4159.2003.02269.x?sid=nlm%3Apubmed
dc.identifier.urihttps://hdl.handle.net/20.500.14352/96203
dc.issue.number5
dc.journal.titleJournal of Neurochemistry
dc.language.isoeng
dc.page.final1210
dc.page.initial1203
dc.publisherWiley
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu612.017
dc.subject.ucmCiencias Biomédicas
dc.subject.unesco24 Ciencias de la Vida
dc.titleExpression of glucose transporter isoform GLUT‐2 and glucokinase genes in human brain
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number88
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery10be4d39-6db9-4c8f-ab13-81da235fb32f
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