Differences in platelet‐rich plasma composition influence bone healing

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dc.contributor.authorAl‐Hamed, Faez Saleh
dc.contributor.authorAbu‐Nada, Lina
dc.contributor.authorRodan, Rania
dc.contributor.authorSarrigiannidis, Stylianos
dc.contributor.authorRamirez‐Garcialuna, José Luis
dc.contributor.authorMoussa, Hanan
dc.contributor.authorElkashty, Osama
dc.contributor.authorGao, Qiman
dc.contributor.authorBasiri, Tayebeh
dc.contributor.authorBaca González, Laura
dc.contributor.authorTorres García Denche, Jesús
dc.contributor.authorRancán, Lisa
dc.contributor.authorTran, Simon D.
dc.contributor.authorLordkipanidzé, Marie
dc.contributor.authorKaartinen, Mari
dc.contributor.authorBadran, Zahi
dc.contributor.authorTamimi, Faleh
dc.date.accessioned2024-01-16T10:42:38Z
dc.date.available2024-01-16T10:42:38Z
dc.date.issued2021-09-27
dc.description.abstractAim: Platelet-rich plasma (PRP) is an autologous blood-derived material that has been used to enhance bone regeneration. Clinical studies, however, reported inconsistent outcomes. This study aimed to assess the effect of changes in leucocyte and PRP (L-PRP) composition on bone defect healing. Materials and Methods: L-PRPs were prepared using different centrifugation methods and their regenerative potential was assessed in an in-vivo rat model. Bilateral critical-size tibial bone defects were created and filled with single-spin L-PRP, double-spin L-PRP, or filtered L-PRP. Empty defects and defects treated with collagen scaffolds served as controls. Rats were euthanized after 2 weeks, and their tibias were collected and analysed using micro-CT and histology. Results: Double-spin L-PRP contained higher concentrations of platelets than singlespin L-PRP and filtered L-PRP. Filtration of single-spin L-PRP resulted in lower concentrations of minerals and metabolites. In vivo, double-spin L-PRP improved bone healing by significantly reducing the size of bone defects (1.08 ± 0.2 mm3) compared to single-spin L-PRP (1.42 ± 0.27 mm3) or filtered L-PRP (1.38 ± 0.28 mm3). There were fewer mast cells, lymphocytes, and macrophages in defects treated with double-spin L-PRP than in those treated with single-spin or filtered L-PRP. Conclusion: The preparation method of L-PRP affects their composition and potential to regenerate bone.en
dc.description.departmentDepto. de Especialidades Clínicas Odontológicas
dc.description.facultyFac. de Odontología
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationAl-Hamed, F. S., Abu-Nada, L., Rodan, R., Sarrigiannidis, S., Ramirez-Garcialuna, J. L., Moussa, H., Elkashty, O., Gao, Q., Basiri, T., Baca, L., Torres, J., Rancan, L., Tran, S. D., Lordkipanidzé, M., Kaartinen, M., Badran, Z., Tamimi, F. Differences in platelet-rich plasma composition influence bone healing. Journal of Clinical Periodontology. 2021;48:1613-1626
dc.identifier.doi10.1111/jcpe.13546
dc.identifier.issn0303-6979
dc.identifier.issn1600-051X
dc.identifier.officialurlhttps//doi.org/10.1111/jcpe.13546
dc.identifier.pmid34517437
dc.identifier.relatedurlhttps://onlinelibrary.wiley.com/doi/full/10.1111/jcpe.13546
dc.identifier.urihttps://hdl.handle.net/20.500.14352/93312
dc.journal.titleJournal of Clinical Periodontology
dc.language.isoeng
dc.page.final1623
dc.page.initial1613
dc.publisherWiley
dc.rightsAttribution-NonCommercial 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subject.cdu61
dc.subject.cdu57.08
dc.subject.cdu616-074/-078
dc.subject.keywordBone formation
dc.subject.keywordBone healing
dc.subject.keywordCritical size defect
dc.subject.keywordPlatelet concentrates
dc.subject.keywordPlatelet-rich plasma
dc.subject.keywordRat surgery
dc.subject.ucmCiencias Biomédicas
dc.subject.ucmBiotecnología
dc.subject.ucmAnálisis clínicos
dc.subject.unesco32 Ciencias Médicas
dc.subject.unesco3302 Tecnología Bioquímica
dc.titleDifferences in platelet‐rich plasma composition influence bone healingen
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number48
dspace.entity.typePublication
relation.isAuthorOfPublication6f2c8d34-b93c-4643-baf4-05272324c197
relation.isAuthorOfPublication412d039f-5b44-405f-800d-ff0afb67ccd0
relation.isAuthorOfPublication.latestForDiscovery6f2c8d34-b93c-4643-baf4-05272324c197
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