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Depletion of the TRF1 telomere-binding protein leads to leaner mice with altered metabolic profiles

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dc.contributor.authorRuano, Jessica Louzame
dc.contributor.authorBejarano, Leire
dc.contributor.authorSerrano, Rosa
dc.contributor.authorDiaz, Ruth Alvarez
dc.contributor.authorFlores Landeira, Juana María
dc.contributor.authorLópez, Ana Cayuela
dc.contributor.authorBlasco, Maria A.
dc.date.accessioned2025-10-22T12:53:47Z
dc.date.available2025-10-22T12:53:47Z
dc.date.issued2025
dc.descriptionAuthor Contributions: MAB, JL and LB had the original idea. MAB secured funding and supervised the research. JL analyzed the results, wrote the paper and performed the experiments. RS was responsible for animal maintenance and assisted with animal experimentation. JMF performed pathological analysis. ACL developed and analyzed the confocal microscopy images, and RAD performed the bioinformatics analysis.
dc.description.abstractTRF1, a component of the telomere shelterin complex, plays crucial roles in telomere protection, telomere length regulation, and stemness. Here, we describe a previously unknown connection between TRF1 and metabolism. Telomere attrition has been linked to obesity. Our study reveals that Trf1-deficient mice exhibit a leaner phenotype, reduced adiposity, and improved glucose tolerance, even when subjected to a high-fat diet, independently of telomere shortening. These findings uncover a previously unknown role of TRF1 in regulating metabolism
dc.description.departmentDepto. de Medicina y Cirugía Animal
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia, Innovación y Universidades (España)
dc.description.sponsorshipEuropean Commission
dc.description.sponsorshipFundación Botín (España)
dc.description.sponsorshipFundación Humanismo y Ciencia
dc.description.statuspub
dc.identifier.citationRuano, J. L., Bejarano, L., Serrano, R., Diaz, R. A., Flores, J. M., López, A. C., & Blasco, M. A. (2025). Depletion of the TRF1 telomere-binding protein leads to leaner mice with altered metabolic profiles. Aging, 17(9), 2410–2429. https://doi.org/10.18632/aging.206320
dc.identifier.doi10.18632/aging.206320
dc.identifier.essn1945-4589
dc.identifier.officialurlhttps://doi.org/10.18632/aging.206320
dc.identifier.pmid40982211
dc.identifier.urihttps://hdl.handle.net/20.500.14352/125250
dc.issue.number9
dc.journal.titleAging
dc.language.isoeng
dc.page.final2429
dc.page.initial2410
dc.publisherImpact Journals
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-82623-R/ES/TELOMEROS Y ENFERMEDAD/
dc.relation.projectIDMICIU/AEI/ 10.13039/ 501100011033
dc.relation.projectIDGA 882385
dc.relation.projectIDPRE2018-083335
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/CPP2021-008483/ES/Desarrollo de una nueva terapia génica para el tratamiento de la Fibrosis Idiopática./
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu636.09
dc.subject.keywordTrf1
dc.subject.keywordFat
dc.subject.keywordLeaner
dc.subject.keywordMetabolism
dc.subject.keywordTelomeres
dc.subject.ucmVeterinaria
dc.subject.unesco3109 Ciencias Veterinarias
dc.titleDepletion of the TRF1 telomere-binding protein leads to leaner mice with altered metabolic profiles
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number17
dspace.entity.typePublication
relation.isAuthorOfPublicationef1f9dc1-ea08-419e-88cc-c4d745982785
relation.isAuthorOfPublication.latestForDiscoveryef1f9dc1-ea08-419e-88cc-c4d745982785

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