Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: Multilayered cross-talks in the setting of coinfections and comorbidities

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dc.contributor.authorKumar, Rahul
dc.contributor.authorCogolludo Torralba, Ángel Luis
dc.contributor.authorPérez Vizcaíno, Francisco
dc.contributor.authorMorales Cano, Daniel
dc.contributor.authorDhillon, Navneet K.
dc.contributor.editorKenneth Stapleford
dc.date.accessioned2024-01-15T10:53:20Z
dc.date.available2024-01-15T10:53:20Z
dc.date.issued2023
dc.description.abstractThe Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and its sublineages pose a new challenge to healthcare systems worldwide due to its ability to efficiently spread in immunized populations and its resistance to currently available therapies. COVID-19, although targeting primarily the respiratory system, is also now well established that later affects every organ in the body. Most importantly, despite the available therapy and vaccine-elicited protection, the long-term consequences of viral infection in breakthrough and asymptomatic individuals are areas of concern. In the past two years, investigators accumulated evidence on how the virus triggers our immune system and the molecular signals involved in the cross-talk between immune cells and structural cells in the pulmonary vasculature to drive pathological lung complications such as endothelial dysfunction and thrombosis. In the review, we emphasize recent updates on the pathophysiological inflammatory and immune responses associated with SARS-CoV-2 infection and their potential long-term consequences that may consequently lead to the development of pulmonary vascular diseases.
dc.description.departmentDepto. de Farmacología y Toxicología
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationKumar R, Aktay-Cetin Ö, Craddock V, Morales-Cano D, Kosanovic D, et al. (2023) Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: Multilayered cross-talks in the setting of coinfections and comorbidities. PLOS Pathogens 19(1): e1011063. https://doi.org/10.1371/journal.ppat.1011063
dc.identifier.doi10.1371/journal.ppat.1011063
dc.identifier.issn1553-7374
dc.identifier.officialurlhttps://doi.org/10.1371/journal.ppat.1011063
dc.identifier.relatedurlhttps://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011063
dc.identifier.urihttps://hdl.handle.net/20.500.14352/93014
dc.issue.number1
dc.journal.titlePlos Pathogens
dc.language.isoeng
dc.publisherPlos
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu616.12
dc.subject.ucmMedicina
dc.subject.unesco3207.04 Patología Cardiovascular
dc.titlePotential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: Multilayered cross-talks in the setting of coinfections and comorbidities
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number19
dspace.entity.typePublication
relation.isAuthorOfPublicationecbfa2d8-58e7-4222-83ea-b70445e2af6a
relation.isAuthorOfPublication77765d19-8a6b-490a-954f-bc3d408d1cff
relation.isAuthorOfPublication.latestForDiscoveryecbfa2d8-58e7-4222-83ea-b70445e2af6a
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