Metallic Nanoparticles—friends or foes in the battle against antibiotic-Resistant Bacteria?

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dc.contributor.authorAmaro Torres, Francisco
dc.contributor.authorMorón García, Álvaro
dc.contributor.authorDíaz del Toro, Silvia
dc.contributor.authorMartín González, Ana María
dc.contributor.authorGutiérrez Fernández, Juan Carlos
dc.date.accessioned2023-06-17T09:06:39Z
dc.date.available2023-06-17T09:06:39Z
dc.date.issued2021-02-12
dc.description.abstractThe rapid spread of antibiotic resistances among bacteria demands novel strategies for infection control, and metallic nanoparticles appear as promising tools because of their unique size and tunable properties that allow their antibacterial effects to be maximized. Furthermore, their diverse mechanisms of action towards multiple cell components have suggested that bacteria could not easily develop resistance against nanoparticles. However, research published over the last decade has proven that bacteria can indeed evolve stable resistance mechanisms upon continuous exposure to metallic nanoparticles. In this review, we summarize the currently known individual and collective strategies employed by bacteria to cope with metallic nanoparticles. Importantly, we also discuss the adverse side effects that bacterial exposure to nanoparticles may have on antibiotic resistance dissemination and that might constitute a challenge for the implementation of nanoparticles as antibacterial agents. Overall, studies discussed in this review point out that careful management of these very promising antimicrobials is necessary to preserve their efficacy for infection control.
dc.description.departmentDepto. de Genética, Fisiología y Microbiología
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía y Competitividad (MINECO)
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/65866
dc.identifier.doi10.3390/microorganisms9020364
dc.identifier.issnElectronic: 2076-2607
dc.identifier.officialurlhttps://doi.org/10.3390/microorganisms9020364
dc.identifier.relatedurlhttps://www.mdpi.com/2076-2607/9/2/364
dc.identifier.urihttps://hdl.handle.net/20.500.14352/8192
dc.issue.number2
dc.journal.titleMicroorganisms
dc.language.isoeng
dc.page.final10
dc.page.initial1
dc.publisherMDPI
dc.relation.projectID(CGL2016-75494-R)
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.cdu579.8
dc.subject.cdu577.18.08
dc.subject.cdu539.2:620.1
dc.subject.keywordNanoparticles
dc.subject.keywordHeavy metals
dc.subject.keywordResistance
dc.subject.keywordAntibiotic resistance
dc.subject.keywordOxidative stress
dc.subject.ucmMicrobiología (Biología)
dc.subject.unesco2414 Microbiología
dc.titleMetallic Nanoparticles—friends or foes in the battle against antibiotic-Resistant Bacteria?
dc.typejournal article
dc.volume.number9
dspace.entity.typePublication
relation.isAuthorOfPublication9517917a-13ff-409d-b08f-bd204a61d258
relation.isAuthorOfPublicatione48abb18-103b-4edc-9081-81a44bc92b44
relation.isAuthorOfPublication0942b309-8e93-4ae5-a284-d49cb191c64b
relation.isAuthorOfPublication.latestForDiscovery9517917a-13ff-409d-b08f-bd204a61d258
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