Highly diastereoselective Staudinger reaction on 5,6-dihydropyrazin-2-(1H)-ones. Synthesis of enantiopure fused oxopiperazino-β-lactams

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dc.contributor.authorViso Beronda, Alma
dc.contributor.authorFernández de la Pradilla Sainz de Aja, Roberto
dc.contributor.authorFlores Aguilar-Amat, Aída
dc.date.accessioned2024-02-05T18:39:13Z
dc.date.available2024-02-05T18:39:13Z
dc.date.issued2006-12-11
dc.description.abstractThe highly diastereoselective synthesis of fused oxopiperazino-β-lactams 2 by Staudinger reaction between functionalized ketenes and 5,6-dihydropyrazin-2(1H)-ones 1 has been carried out. Further cleavage of the β-lactam ring produced 2-oxopiperazine-3-acetic acid derivatives 7 with no epimerization and in good yields.
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipDirección General de Ingresos
dc.description.statuspub
dc.identifier.citationViso, Alma, et al. «Highly Diastereoselective Staudinger Reaction on 5,6-Dihydropyrazin-2-(1H)-Ones. Synthesis of Enantiopure Fused Oxopiperazino-β-Lactams». Tetrahedron Letters, vol. 47, n.o 50, diciembre de 2006, pp. 8911-15. DOI.org (Crossref), https://doi.org/10.1016/j.tetlet.2006.10.044.
dc.identifier.doi10.1016/j.tetlet.2006.10.044
dc.identifier.officialurlhttps://doi.org/10.1016/j.tetlet.2006.10.044
dc.identifier.urihttps://hdl.handle.net/20.500.14352/99180
dc.journal.titleTetrahedron Letters
dc.language.isoeng
dc.page.final8915
dc.page.initial8911
dc.publisherElsevier
dc.relation.projectIDinfo:eu-repo/grantAgreement/BQU2003-02921
dc.relation.projectIDinfo:eu-repo/grantAgreement/CTQ2005-04632/BQU
dc.rights.accessRightsrestricted access
dc.subject.keywordβ-Lactams
dc.subject.keywordPiperazines
dc.subject.keywordAsymmetric synthesis
dc.subject.ucmQuímica orgánica (Química)
dc.subject.unesco2306 Química Orgánica
dc.titleHighly diastereoselective Staudinger reaction on 5,6-dihydropyrazin-2-(1H)-ones. Synthesis of enantiopure fused oxopiperazino-β-lactams
dc.typejournal article
dc.volume.number47
dspace.entity.typePublication
relation.isAuthorOfPublication2190c837-be93-4816-bf4a-6695e683f4c2
relation.isAuthorOfPublication.latestForDiscovery2190c837-be93-4816-bf4a-6695e683f4c2

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