Risk of dementia among antidepressant elderly users: A population-based cohort analysis in Spain

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dc.contributor.authorSantandreu, Javier
dc.contributor.authorCaballero, Francisco Félix
dc.contributor.authorGómez-Serranillos Cuadrado, María Pilar
dc.contributor.authorGonzález Burgos, Elena María
dc.date.accessioned2024-01-12T09:01:24Z
dc.date.available2024-01-12T09:01:24Z
dc.date.issued2024-03-15
dc.description.abstractThe use of antidepressants with anticholinergic effects has been associated with an increased risk of dementia. However, the results published are contradictory. The aim of the study is to compare the risk of developing dementia in elderly who were prescribed tricyclic antidepressants (TCA) versus those who were prescribed selective serotonin reuptake inhibitors (SSRIs) and other antidepressants (OA). A prospective population-based cohort study was performed using the Spanish Database for Pharmacoepidemiological Research in Primary Care (BIFAP) data (from 2005 to 2018). The cohort study included 62,928 patients age ≥ 60 without dementia and with antidepressant long-term monotherapy. Patients were divided into exposure antidepressant groups based on ATC system [TCA, SSRIs users and OAs users]. The risk of dementia was calculated by Cox regression models, providing hazard ratios (HR) and 95 % confidence intervals. The Kaplan-Meier model was used for survival analysis. Chi2 test was used as association test. The results showed SSRI users had higher dementia risk than TCA users (HR = 1.864; 95%CI = 1.624–2.140). Moreover, OA users had also significant risk of dementia (HR = 2.103; 95%CI = 1.818–2.431). Several limitations are the variation of the trend in the prescription of antidepressants, the small number of patients that use some antidepressants, the lack of information related to the dose, or socioeconomic characteristics, the use of antidepressant drugs for other indications, or the therapeutic compliance. Our findings showed that older users of SSRI and OA have more risk of developing dementia than TCA elderly users. However, additional studies would be needed.
dc.description.departmentDepto. de Farmacología, Farmacognosia y Botánica
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationSantandreu J, Caballero FF, Gómez-Serranillos MP, González-Burgos E. Risk of dementia among antidepressant elderly users: A population-based cohort analysis in Spain. J Affect Disord 2024;349:54-61
dc.identifier.doi10.1016/j.jad.2024.01.002
dc.identifier.essn1573-2517
dc.identifier.issn0165-0327
dc.identifier.officialurlhttps://doi.org/10.1016/j.jad.2024.01.002
dc.identifier.urihttps://hdl.handle.net/20.500.14352/92670
dc.journal.titleJournal of Affective Disorders
dc.language.isoeng
dc.page.final61
dc.page.initial54
dc.page.total8
dc.publisherElsevier
dc.rightsAttribution-NonCommercial 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subject.cdu615.2
dc.subject.cdu616.894-053.9
dc.subject.cdu615.03
dc.subject.keywordAntidepressants
dc.subject.keywordDementia
dc.subject.keywordBIFAP
dc.subject.keywordCohort study
dc.subject.keywordAnticholinergic
dc.subject.ucmCiencias Biomédicas
dc.subject.unesco32 Ciencias Médicas
dc.titleRisk of dementia among antidepressant elderly users: A population-based cohort analysis in Spain
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number349
dspace.entity.typePublication
relation.isAuthorOfPublicationa74693cd-ed68-4c7a-9c58-0b391d1bfdd2
relation.isAuthorOfPublication69510424-a309-4eeb-b62d-df87d56e477a
relation.isAuthorOfPublication.latestForDiscoverya74693cd-ed68-4c7a-9c58-0b391d1bfdd2
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