Signalling by NO-induced protein S-nitrosylation and S-glutathionylation: Convergences and divergences

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dc.contributor.authorMartínez Ruiz, Antonio
dc.contributor.authorLamas, Santiago
dc.date.accessioned2024-04-05T11:10:21Z
dc.date.available2024-04-05T11:10:21Z
dc.date.issued2007-07-15
dc.description.abstractThe role of nitric oxide in several signalling routes has been clearly established. In recent years increasing attention has been paid to its ability to produce covalent protein post-translational modifications in conjunction with other reactive oxygen and nitrogen species. Among these, the modification of cysteine residues has been shown to be of particular importance due to the functional relevance of many of them. In this review, we focus on the modification of the cysteine thiol by incorporation of a NO moiety (S-nitrosylation) or of a glutathione moiety (S-glutathionylation). Both modifications are produced by different reactions induced by nitric oxide-related species. We discuss the differences and similarities of both modifications, and their relationships, in regard to the biochemical mechanisms that produce them, including the enzymatic activities that may catalyze some of them and their subcellular compartmentalization. Even when biochemical knowledge is one step ahead of the demonstration of their pathophysiological relevance, we also describe the potential role of both modifications in several processes in which both post-translational modifications are involved. © 2007 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Educación y Ciencia
dc.description.sponsorshipMinisterio de Sanidad y Consumo
dc.description.statuspub
dc.identifier.doi10.1016/j.cardiores.2007.03.016
dc.identifier.issn0008-6363
dc.identifier.officialurlhttps://academic.oup.com/cardiovascres/article/75/2/220/295716
dc.identifier.urihttps://hdl.handle.net/20.500.14352/102745
dc.issue.number75
dc.journal.titleCardiovascular research
dc.language.isoeng
dc.page.final228
dc.page.initial220
dc.relation.projectIDSAF 2006-02410
dc.relation.projectIDSAF 2003-01039
dc.relation.projectIDCP03/0025
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu577.1
dc.subject.cdu577.2
dc.subject.keywordNitric oxide
dc.subject.keywordPost-translational modifications
dc.subject.keywordOxidative stress
dc.subject.keywordGlutathione
dc.subject.ucmBioquímica (Farmacia)
dc.subject.ucmBiología molecular (Farmacia)
dc.subject.unesco2302 Bioquímica
dc.titleSignalling by NO-induced protein S-nitrosylation and S-glutathionylation: Convergences and divergences
dc.typejournal article
dc.type.hasVersionAM
dspace.entity.typePublication
relation.isAuthorOfPublicationeec0b303-34c9-47dd-9ec6-704b6c6c7acd
relation.isAuthorOfPublication.latestForDiscoveryeec0b303-34c9-47dd-9ec6-704b6c6c7acd
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