Role for the ankyrin eukaryotic-like genes of Legionella pneumophila in parasitism of protozoan hosts and human macrophages
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2008
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Wiley
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Habyarimana F, Al-khodor S, Kalia A, Graham JE, Price CT, García MT, Abu Kwaik Y. (2008). Role for the ankyrin eukaryotic-like genes of Legionella pneumophila in parasitism of protozoan hosts and human macrophages. Environmental Microbiology, 10(6):1460–1474. https://doi.org/10.1111/j.1462-2920.2007.01560.x
Abstract
Legionella pneumophila is ubiquitous in aquatic environments, invading protozoa and causing pneumonia in humans. The L. pneumophila genome encodes a multigene family of 11 ankyrin (ank) genes. Isogenic mutants indicate AnkH and AnkJ are involved in robust intracellular replication in protozoa (Acanthamoeba polyphaga, Hartmanella vermiformis, Tetrahymena pyriformis) and human macrophages, with upregulation mediated by RpoS. The proteins’ modularity suggests a role in phagosome biogenesis and adaptation to diverse hosts. Thus, co-evolution with protozoa may have enabled L. pneumophila to parasitize humans.
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Funding: Y.A.K. supported by Public Health Service Awards R01AI43965 and R01AI069321 (NIAID) and Kentucky Research Challenge Trust Fund.