Protection against Tuberculosis in Eurasian Wild Boar Vaccinated with Heat-Inactivated Mycobacterium bovis

Simple item page
dc.contributor.authorDieli, Francesco
dc.contributor.authorGarrido, Joseba M.
dc.contributor.authorSevilla, Iker A.
dc.contributor.authorBeltrán-Beck, Beatriz
dc.contributor.authorMinguijón, Esmeralda
dc.contributor.authorBallesteros, Cristina
dc.contributor.authorGalindo, Ruth C.
dc.contributor.authorBoadella, Mariana
dc.contributor.authorLyashchenko, Konstantin P.
dc.contributor.authorRomero Martínez, Beatriz
dc.contributor.authorGeijo, Maria Victoria
dc.contributor.authorRuiz Fons, Francisco
dc.contributor.authorAranaz Martín, Alicia
dc.contributor.authorJuste, Ramón A.
dc.contributor.authorVicente, Joaquín
dc.contributor.authorde la Fuente, José
dc.contributor.authorGortázar, Christian
dc.date.accessioned2023-06-20T04:21:11Z
dc.date.available2023-06-20T04:21:11Z
dc.date.issued2011
dc.description.abstractTuberculosis (TB) caused by Mycobacterium bovis and closely related members of the Mycobacterium tuberculosis complex continues to affect humans and animals worldwide and its control requires vaccination of wildlife reservoir species such as Eurasian wild boar (Sus scrofa). Vaccination efforts for TB control in wildlife have been based primarily on oral live BCG formulations. However, this is the first report of the use of oral inactivated vaccines for controlling TB in wildlife. In this study, four groups of 5 wild boar each were vaccinated with inactivated M. bovis by the oral and intramuscular routes, vaccinated with oral BCG or left unvaccinated as controls. All groups were later challenged with a field strain of M. bovis. The results of the IFN-gamma response, serum antibody levels, M. bovis culture, TB lesion scores, and the expression of C3 and MUT genes were compared between these four groups. The results suggested that vaccination with heat-inactivated M. bovis or BCG protect wild boar from TB. These results also encouraged testing combinations of BCG and inactivated M. bovis to vaccinate wild boar against TB. Vaccine formulations using heat-inactivated M. bovis for TB control in wildlife would have the advantage of being environmentally safe and more stable under field conditions when compared to live BCG vaccines. The antibody response and MUT expression levels can help differentiating between vaccinated and infected wild boar and as correlates of protective response in vaccinated animals. These results suggest that vaccine studies in free-living wild boar are now possible to reveal the full potential of protecting against TB using oral M. bovis inactivated and BCG vaccines
dc.description.facultyCentro de Vigilancia Sanitaria Veterinaria (VISAVET)
dc.description.refereedTRUE
dc.description.sponsorshipUnión Europea. FP7
dc.description.sponsorshipMinisterio de Ciencia e Innovación (MICINN)
dc.description.sponsorshipInstituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA)
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/39711
dc.identifier.doi10.1371/journal.pone.0024905
dc.identifier.issn1932-6203
dc.identifier.officialurlhttp://dx.doi.org/10.1371/journal.pone.0024905
dc.identifier.urihttps://hdl.handle.net/20.500.14352/45199
dc.issue.number9
dc.journal.titlePLoS ONE
dc.language.isoeng
dc.page.initiale24905
dc.relation.projectIDTB-STEP (212414)
dc.relation.projectIDFAU 2006-00017- C03-01
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.ucmVeterinaria
dc.subject.unesco3109 Ciencias Veterinarias
dc.titleProtection against Tuberculosis in Eurasian Wild Boar Vaccinated with Heat-Inactivated Mycobacterium bovis
dc.typejournal article
dc.volume.number6
dspace.entity.typePublication
relation.isAuthorOfPublication6b436065-5bf3-4a47-86c1-57e869d29a51
relation.isAuthorOfPublication4243d2aa-49ad-4afc-8924-8fbf5d0feae7
relation.isAuthorOfPublication.latestForDiscovery6b436065-5bf3-4a47-86c1-57e869d29a51
Download
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
455.pdf
Size:
441.12 KB
Format:
Adobe Portable Document Format
downoload Download
Collections
Artículos