Functionalization of photosensitized silica nanoparticles for advanced photodynamic therapy of cancer

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dc.contributor.authorPrieto Montero, Ruth
dc.contributor.authorPrieto Castañeda, Alejandro
dc.contributor.authorKatsumiti, Alberto
dc.contributor.authorCajaraville, Miren P.
dc.contributor.authorRodríguez Agarrabeitia, Antonia
dc.contributor.authorOrtiz García, María Josefa
dc.contributor.authorMartínez Martínez, Virginia
dc.dateReceived: 28 May 2021 / Accepted: 16 June 2021 / Published: 21 June 2021
dc.date.accessioned2023-06-17T09:11:53Z
dc.date.available2023-06-17T09:11:53Z
dc.date.issued2021-06-21
dc.description.abstractBODIPY dyes have recently attracted attention as potential photosensitizers. In this work, commercial and novel photosensitizers (PSs) based on BODIPY chromophores (haloBODIPYs and orthogonal dimers strategically designed with intense bands in the blue, green or red region of the visible spectra and high singlet oxygen production) were covalently linked to mesoporous silica nanoparticles (MSNs) further functionalized with PEG and folic acid (FA). MSNs approximately 50 nm in size with different functional groups were synthesized to allow multiple alternatives of PS-PEG-FA decoration of their external surface. Different combinations varying the type of PS (commercial Rose Bengal, Thionine and Chlorine e6 or custom-made BODIPY-based), the linkage design, and the length of PEG are detailed. All the nanosystems were physicochemically characterized (morphology, diameter, size distribution and PS loaded amount) and photophysically studied (absorption capacity, fluorescence efficiency, and singlet oxygen production) in suspension. For the most promising PS-PEG-FA silica nanoplatforms, the biocompatibility in dark conditions and the phototoxicity under suitable irradiation wavelengths (blue, green, or red) at regulated light doses (10–15 J/cm2) were compared with PSs free in solution in HeLa cells in vitro.en
dc.description.departmentSección Deptal. de Química Orgánica (Óptica y Optometría)
dc.description.facultyFac. de Óptica y Optometría
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía, Comercio y Empresa (España)
dc.description.sponsorshipGobierno Vasco
dc.description.sponsorshipUniversidad del País Vasco
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/67533
dc.identifier.citationPrieto Montero, R., Prieto Castañeda, A., Katsumiti, A. et al. «Functionalization of Photosensitized Silica Nanoparticles for Advanced Photodynamic Therapy of Cancer». International Journal of Molecular Sciences, vol. 22, n.o 12, junio de 2021, p. 6618. DOI.org (Crossref), https://doi.org/10.3390/ijms22126618.
dc.identifier.doi10.3390/ijms22126618
dc.identifier.issn1422-0067
dc.identifier.officialurlhttps://doi.org/10.3390/ijms22126618
dc.identifier.relatedurlhttps://www.mdpi.com/1422-0067/22/12/6618
dc.identifier.urihttps://hdl.handle.net/20.500.14352/8376
dc.issue.number6618
dc.journal.titleInternational Journal of Molecular Sciences
dc.language.isoeng
dc.page.total23
dc.publisherMDPI
dc.relation.projectIDMAT2017-83856-C3-2-P, MAT2017-83856-C3-3-P, PID2020-114755GB-C3 and CTM2016-81130-R;
dc.relation.projectID(IT912-16; IT-1302-19)
dc.relation.projectID(COLAB19/01)
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.cdu620.3
dc.subject.cdu615.849.7
dc.subject.cdu616‑006.04
dc.subject.cdu547
dc.subject.cdu543.42.6
dc.subject.cdu577.164.17
dc.subject.keywordBODIPY-based photosensitizers
dc.subject.keywordFunctionalized silica nanoparticles
dc.subject.keywordFolic acid
dc.subject.keywordPEG
dc.subject.keywordPhotodynamic therapy
dc.subject.keywordHeLa cells
dc.subject.keyword(Photo) toxicity
dc.subject.ucmBioquímica (Química)
dc.subject.ucmQuímica orgánica (Química)
dc.subject.ucmOncología
dc.subject.unesco2306 Química Orgánica
dc.subject.unesco3201.01 Oncología
dc.titleFunctionalization of photosensitized silica nanoparticles for advanced photodynamic therapy of canceren
dc.typejournal article
dc.volume.number22
dspace.entity.typePublication
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relation.isAuthorOfPublication0486160c-3df6-4270-bf91-3e96cd33d85d
relation.isAuthorOfPublication07f337af-8a30-4929-81db-4e92176e5c87
relation.isAuthorOfPublication.latestForDiscoverybee889c2-938d-48d9-8748-01e3c8bf5614
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