Functionalization of photosensitized silica nanoparticles for advanced photodynamic therapy of cancer
dc.contributor.author | Prieto Montero, Ruth | |
dc.contributor.author | Prieto Castañeda, Alejandro | |
dc.contributor.author | Katsumiti, Alberto | |
dc.contributor.author | Cajaraville, Miren P. | |
dc.contributor.author | Rodríguez Agarrabeitia, Antonia | |
dc.contributor.author | Ortiz García, María Josefa | |
dc.contributor.author | Martínez Martínez, Virginia | |
dc.date | Received: 28 May 2021 / Accepted: 16 June 2021 / Published: 21 June 2021 | |
dc.date.accessioned | 2023-06-17T09:11:53Z | |
dc.date.available | 2023-06-17T09:11:53Z | |
dc.date.issued | 2021-06-21 | |
dc.description.abstract | BODIPY dyes have recently attracted attention as potential photosensitizers. In this work, commercial and novel photosensitizers (PSs) based on BODIPY chromophores (haloBODIPYs and orthogonal dimers strategically designed with intense bands in the blue, green or red region of the visible spectra and high singlet oxygen production) were covalently linked to mesoporous silica nanoparticles (MSNs) further functionalized with PEG and folic acid (FA). MSNs approximately 50 nm in size with different functional groups were synthesized to allow multiple alternatives of PS-PEG-FA decoration of their external surface. Different combinations varying the type of PS (commercial Rose Bengal, Thionine and Chlorine e6 or custom-made BODIPY-based), the linkage design, and the length of PEG are detailed. All the nanosystems were physicochemically characterized (morphology, diameter, size distribution and PS loaded amount) and photophysically studied (absorption capacity, fluorescence efficiency, and singlet oxygen production) in suspension. For the most promising PS-PEG-FA silica nanoplatforms, the biocompatibility in dark conditions and the phototoxicity under suitable irradiation wavelengths (blue, green, or red) at regulated light doses (10–15 J/cm2) were compared with PSs free in solution in HeLa cells in vitro. | en |
dc.description.department | Sección Deptal. de Química Orgánica (Óptica y Optometría) | |
dc.description.faculty | Fac. de Óptica y Optometría | |
dc.description.refereed | TRUE | |
dc.description.sponsorship | Ministerio de Economía, Comercio y Empresa (España) | |
dc.description.sponsorship | Gobierno Vasco | |
dc.description.sponsorship | Universidad del País Vasco | |
dc.description.status | pub | |
dc.eprint.id | https://eprints.ucm.es/id/eprint/67533 | |
dc.identifier.citation | Prieto Montero, R., Prieto Castañeda, A., Katsumiti, A. et al. «Functionalization of Photosensitized Silica Nanoparticles for Advanced Photodynamic Therapy of Cancer». International Journal of Molecular Sciences, vol. 22, n.o 12, junio de 2021, p. 6618. DOI.org (Crossref), https://doi.org/10.3390/ijms22126618. | |
dc.identifier.doi | 10.3390/ijms22126618 | |
dc.identifier.issn | 1422-0067 | |
dc.identifier.officialurl | https://doi.org/10.3390/ijms22126618 | |
dc.identifier.relatedurl | https://www.mdpi.com/1422-0067/22/12/6618 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14352/8376 | |
dc.issue.number | 6618 | |
dc.journal.title | International Journal of Molecular Sciences | |
dc.language.iso | eng | |
dc.page.total | 23 | |
dc.publisher | MDPI | |
dc.relation.projectID | MAT2017-83856-C3-2-P, MAT2017-83856-C3-3-P, PID2020-114755GB-C3 and CTM2016-81130-R; | |
dc.relation.projectID | (IT912-16; IT-1302-19) | |
dc.relation.projectID | (COLAB19/01) | |
dc.rights | Atribución 3.0 España | |
dc.rights.accessRights | open access | |
dc.rights.uri | https://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject.cdu | 620.3 | |
dc.subject.cdu | 615.849.7 | |
dc.subject.cdu | 616‑006.04 | |
dc.subject.cdu | 547 | |
dc.subject.cdu | 543.42.6 | |
dc.subject.cdu | 577.164.17 | |
dc.subject.keyword | BODIPY-based photosensitizers | |
dc.subject.keyword | Functionalized silica nanoparticles | |
dc.subject.keyword | Folic acid | |
dc.subject.keyword | PEG | |
dc.subject.keyword | Photodynamic therapy | |
dc.subject.keyword | HeLa cells | |
dc.subject.keyword | (Photo) toxicity | |
dc.subject.ucm | Bioquímica (Química) | |
dc.subject.ucm | Química orgánica (Química) | |
dc.subject.ucm | Oncología | |
dc.subject.unesco | 2306 Química Orgánica | |
dc.subject.unesco | 3201.01 Oncología | |
dc.title | Functionalization of photosensitized silica nanoparticles for advanced photodynamic therapy of cancer | en |
dc.type | journal article | |
dc.volume.number | 22 | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | bee889c2-938d-48d9-8748-01e3c8bf5614 | |
relation.isAuthorOfPublication | 0486160c-3df6-4270-bf91-3e96cd33d85d | |
relation.isAuthorOfPublication | 07f337af-8a30-4929-81db-4e92176e5c87 | |
relation.isAuthorOfPublication.latestForDiscovery | bee889c2-938d-48d9-8748-01e3c8bf5614 |
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