Development of sustainable synthesis of glucuronic acid glycodendrimers using ball milling and microwave-assisted CuAAC reaction

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https://doi.org/10.1039/D1NJ06132A

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2022

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Royal Society of Chemistry
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https://hdl.handle.net/20.500.14352/96510

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García-Oliva C, Merchán A, Perona A, Hoyos P, Rumbero Á, Hernáiz MJ. Development of sustainable synthesis of glucuronic acid glycodendrimers using ball milling and microwave-assisted CuAAC reaction. New J Chem 2022;46:6389–93. https://doi.org/10.1039/D1NJ06132A.

Abstract

Two green strategies for copper-catalyzed azide-alkyne cycloaddition reaction based on two activation pathways, solvent free mechanochemistry and microwave irradiation using a recycable biosolvent, are reported for the synthesis of glucuronic acid glycodendrimers with good conversions (99%), the MW pathway being the ideal tool (90% yield in 90 min).

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Ciencias Biomédicas, Ciencias, Farmacia, Química farmaceútica, Química, Química orgánica (Química)

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23 Química, 2306 Química Orgánica, 2306.06 Química de Los Hidratos de Carbono, 3303 Ingeniería y Tecnología Químicas, 3303.05 Síntesis Química

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