Association between anti-Anisakis simplex antibodies and interleukin-7 levels
dc.contributor.author | Cuéllar Del Hoyo, María Del Carmen | |
dc.contributor.author | Rodero Martínez, Marta | |
dc.contributor.author | Pérez-Griera, Jaime | |
dc.contributor.author | Galindo-Regal, Lorena | |
dc.contributor.author | Lopez-Chulia, Francisca | |
dc.contributor.author | García-Ballesteros, Carlos | |
dc.contributor.author | Andreu-Ballester, Juan Carlos | |
dc.date.accessioned | 2024-03-05T14:14:04Z | |
dc.date.available | 2024-03-05T14:14:04Z | |
dc.date.issued | 2022-08-11 | |
dc.description.abstract | IL-7 is a crucial factor for the development of lymphocytes, and it is absolutely necessary for γδ T cells. Mice deficient in L-7 have a deficit of B and αβ T lymphocytes, and an absence of mature γδ TCR cells. IL-7 is essential for the survival, development and maturation of Schistosoma sp., although its production is associated with protection against intestinal helminths. The presence of anti-Anisakis simplex antibodies, especially IgA, is related to a lower frequency in CD3 + CD56 + αβ + lymphocytes and all subpopulations of γδ T cells. In this work, the relationship of IL-7 with humoral and cellular responses against A. simplex in 100 healthy subjects was studied. We have found significantly higher IL-7 levels in anti-A. simplex IgA-positive subjects (p < 0.001). The positivity of anti-A. simplex IgA was associated with a significant reduction in the frequency of CD3 + αβ+ (p < 0.01), CD3 + CD4 + αβ+, CD3 + CD8 + αβ+, CD3 + CD56 + αβ+, CD3 + γδ+, CD3 + CD4-CD8-γδ+ and CD3 + CD56 + γδ+ (p < 0.05) cells. In the case of NKT cells, this same phenomenon was also associated with IgE positivity. There was a weak inverse correlation (Spearman) of IL-7 levels with the frequencies of CD3 + CD4 + αβ+ (-0.125, p = 0.047), CD3 + CD8 + αβ+ (-0.204, p = 0.032), CD3 + CD56 + αβ+ (-0.247, p = 0.007), CD3 + γδ+ (-0.267, p = 0.007), CD3 + CD4-CD8-γδ+ (-0.266, p = 0.003), and CD3 + CD8 + γδ + (-0.302, p = 0.002) cells. The role of NKT cells in the anti-A. simplex response was confirmed and an association between IL and 7 levels and specific antibodies, especially IgA, was demonstrated. The higher production of IL-7 would represent a compensatory mechanism in response to the reduction in lymphocyte populations associated with the response against this parasite. | |
dc.description.department | Depto. de Microbiología y Parasitología | |
dc.description.faculty | Fac. de Farmacia | |
dc.description.refereed | TRUE | |
dc.description.status | pub | |
dc.identifier.citation | Cuéllar C, Rodero M, Pérez-Griera J, Galindo-Regal L, Lopez-Chulia F, García-Ballesteros C, Carlos Andreu-Ballester J. Association between anti-Anisakis simplex antibodies and interleukin-7 levels. Int Immunopharmacol. 2022 Oct;111:109134. doi: 10.1016/j.intimp.2022.109134. Epub 2022 Aug 11. PMID: 35964412. | |
dc.identifier.doi | 10.1016/j.intimp.2022.109134 | |
dc.identifier.issn | 1567-5769 | |
dc.identifier.officialurl | https://www.sciencedirect.com/science/article/pii/S156757692200618X?via%3Dihub | |
dc.identifier.uri | https://hdl.handle.net/20.500.14352/101964 | |
dc.journal.title | International Immunopharmacology | |
dc.language.iso | eng | |
dc.page.initial | 109134 | |
dc.publisher | Elsevier | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | en |
dc.rights.accessRights | embargoed access | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject.cdu | 577.1 | |
dc.subject.cdu | 577.2 | |
dc.subject.keyword | Anisakis simplex | |
dc.subject.keyword | Interleukin-7 | |
dc.subject.keyword | NKT cells | |
dc.subject.keyword | Specific antibodies | |
dc.subject.keyword | γδ+ T cells | |
dc.subject.ucm | Ciencias Biomédicas | |
dc.subject.ucm | Bioquímica (Farmacia) | |
dc.subject.ucm | Biología molecular (Farmacia) | |
dc.subject.unesco | 3207.12 Parasitología | |
dc.title | Association between anti-Anisakis simplex antibodies and interleukin-7 levels | |
dc.type | journal article | |
dc.type.hasVersion | EVoR | |
dc.volume.number | 111 | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 6c555fb4-e29c-4463-8062-a9699fcebaa6 | |
relation.isAuthorOfPublication | 5b09d749-d306-40df-b523-4ab0a479f162 | |
relation.isAuthorOfPublication.latestForDiscovery | 6c555fb4-e29c-4463-8062-a9699fcebaa6 |
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