Association between anti-Anisakis simplex antibodies and interleukin-7 levels

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dc.contributor.authorCuéllar Del Hoyo, María Del Carmen
dc.contributor.authorRodero Martínez, Marta
dc.contributor.authorPérez-Griera, Jaime
dc.contributor.authorGalindo-Regal, Lorena
dc.contributor.authorLopez-Chulia, Francisca
dc.contributor.authorGarcía-Ballesteros, Carlos
dc.contributor.authorAndreu-Ballester, Juan Carlos
dc.date.accessioned2024-03-05T14:14:04Z
dc.date.available2024-03-05T14:14:04Z
dc.date.issued2022-08-11
dc.description.abstractIL-7 is a crucial factor for the development of lymphocytes, and it is absolutely necessary for γδ T cells. Mice deficient in L-7 have a deficit of B and αβ T lymphocytes, and an absence of mature γδ TCR cells. IL-7 is essential for the survival, development and maturation of Schistosoma sp., although its production is associated with protection against intestinal helminths. The presence of anti-Anisakis simplex antibodies, especially IgA, is related to a lower frequency in CD3 + CD56 + αβ + lymphocytes and all subpopulations of γδ T cells. In this work, the relationship of IL-7 with humoral and cellular responses against A. simplex in 100 healthy subjects was studied. We have found significantly higher IL-7 levels in anti-A. simplex IgA-positive subjects (p < 0.001). The positivity of anti-A. simplex IgA was associated with a significant reduction in the frequency of CD3 + αβ+ (p < 0.01), CD3 + CD4 + αβ+, CD3 + CD8 + αβ+, CD3 + CD56 + αβ+, CD3 + γδ+, CD3 + CD4-CD8-γδ+ and CD3 + CD56 + γδ+ (p < 0.05) cells. In the case of NKT cells, this same phenomenon was also associated with IgE positivity. There was a weak inverse correlation (Spearman) of IL-7 levels with the frequencies of CD3 + CD4 + αβ+ (-0.125, p = 0.047), CD3 + CD8 + αβ+ (-0.204, p = 0.032), CD3 + CD56 + αβ+ (-0.247, p = 0.007), CD3 + γδ+ (-0.267, p = 0.007), CD3 + CD4-CD8-γδ+ (-0.266, p = 0.003), and CD3 + CD8 + γδ + (-0.302, p = 0.002) cells. The role of NKT cells in the anti-A. simplex response was confirmed and an association between IL and 7 levels and specific antibodies, especially IgA, was demonstrated. The higher production of IL-7 would represent a compensatory mechanism in response to the reduction in lymphocyte populations associated with the response against this parasite.
dc.description.departmentDepto. de Microbiología y Parasitología
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationCuéllar C, Rodero M, Pérez-Griera J, Galindo-Regal L, Lopez-Chulia F, García-Ballesteros C, Carlos Andreu-Ballester J. Association between anti-Anisakis simplex antibodies and interleukin-7 levels. Int Immunopharmacol. 2022 Oct;111:109134. doi: 10.1016/j.intimp.2022.109134. Epub 2022 Aug 11. PMID: 35964412.
dc.identifier.doi10.1016/j.intimp.2022.109134
dc.identifier.issn1567-5769
dc.identifier.officialurlhttps://www.sciencedirect.com/science/article/pii/S156757692200618X?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/20.500.14352/101964
dc.journal.titleInternational Immunopharmacology
dc.language.isoeng
dc.page.initial109134
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsembargoed access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu577.1
dc.subject.cdu577.2
dc.subject.keywordAnisakis simplex
dc.subject.keywordInterleukin-7
dc.subject.keywordNKT cells
dc.subject.keywordSpecific antibodies
dc.subject.keywordγδ+ T cells
dc.subject.ucmCiencias Biomédicas
dc.subject.ucmBioquímica (Farmacia)
dc.subject.ucmBiología molecular (Farmacia)
dc.subject.unesco3207.12 Parasitología
dc.titleAssociation between anti-Anisakis simplex antibodies and interleukin-7 levels
dc.typejournal article
dc.type.hasVersionEVoR
dc.volume.number111
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery6c555fb4-e29c-4463-8062-a9699fcebaa6
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