Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives

Abstract

Nitrosoarenes exhibit a variety of biological and pharmacological activities. This review uncovers their utility as therapeutic agents, which extends to oxidative stress regulation, DNA damage and repair interaction, cyclin-dependent kinase inhibitors, anticancer, antiviral, antibacterial, antifungal, antiparasitic, anti-inflammatory, and other miscellaneous effects. The synthesis of the most relevant targets is also reviewed.