Adopting a High-Polyphenolic Diet Is Associated with an Improved Glucose Profile: Prospective Analysis within the PREDIMED-Plus Trial
dc.contributor.author | Tresserra Rimbau, Anna | |
dc.contributor.author | Castro Barquero, Sara | |
dc.contributor.author | Becerra Tomás, Nerea | |
dc.contributor.author | Babio, Nancy | |
dc.contributor.author | Martínez González, Miguel Ángel | |
dc.contributor.author | Corella, Dolores | |
dc.contributor.author | Fitó, Montserrat | |
dc.contributor.author | Romaguera, Dora | |
dc.contributor.author | Vioque, Jesús | |
dc.contributor.author | Alonso Gómez, Ángel M. | |
dc.contributor.author | Wärnberg, Julia | |
dc.contributor.author | Martínez, José Alfredo | |
dc.contributor.author | Serra Majem, Luís | |
dc.contributor.author | Estruch, Ramon | |
dc.contributor.author | Tinahones, Francisco J. | |
dc.contributor.author | Lapetra, José | |
dc.contributor.author | Pintó, Xavier | |
dc.contributor.author | Tur, Josep A. | |
dc.contributor.author | López Miranda, José | |
dc.contributor.author | Cano Ibáñez, Naomi | |
dc.contributor.author | Delgado Rodríguez, Miguel | |
dc.contributor.author | Matía Martín, Pilar | |
dc.contributor.author | Daimiel, Lidia | |
dc.contributor.author | Martín Sánchez, Vicente | |
dc.contributor.author | Vidal, Josep | |
dc.contributor.author | Vázquez, Clotilde | |
dc.contributor.author | Ros, Emilio | |
dc.contributor.author | Basterra, Francisco Javier | |
dc.contributor.author | Fernández de la Puente, María | |
dc.contributor.author | Asensio, Eva María | |
dc.contributor.author | Castañer, Olga | |
dc.contributor.author | Bullón Vela, Vanessa | |
dc.contributor.author | Tojal Sierra, Lucas | |
dc.contributor.author | Gómez Gracia, Enrique | |
dc.contributor.author | Cases Pérez, Eugenio | |
dc.contributor.author | Konieczna, Jadwiga | |
dc.contributor.author | García Ríos, Antonio | |
dc.contributor.author | Casañas Quintana, Tamara | |
dc.contributor.author | Bernal López, María Rosa | |
dc.contributor.author | Santos Lozano, José Manuel | |
dc.contributor.author | Esteve Luque, Virginia | |
dc.contributor.author | Bouzas, Cristina | |
dc.contributor.author | Vázquez Ruiz, Zenaida | |
dc.contributor.author | Palau Galindo, Antoni | |
dc.contributor.author | Barragan, Rocio | |
dc.contributor.author | López Grau, Mercè | |
dc.contributor.author | Razquín, Cristina | |
dc.contributor.author | Goicolea Güemez, Leire | |
dc.contributor.author | Toledo, Estefanía | |
dc.contributor.author | Vergaz, Manel Vila | |
dc.contributor.author | Lamuela Raventós, Rosa María | |
dc.contributor.author | Salas Salvadó, Jordi | |
dc.date.accessioned | 2023-06-22T12:53:02Z | |
dc.date.available | 2023-06-22T12:53:02Z | |
dc.date.issued | 2022-02-01 | |
dc.description | The PREDIMED-Plus trial was supported by the Spanish Institutions for funding scientific biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (six coordinated Fondo de Investigaciones Sanitarias projects leaded by J.S.-S. and J.V. (Josep Vidal), including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, PI20/01158)), the Especial Action Project entitled Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus grant to J.S.-S., European Research Council (Advanced Research Grant 2014–2019, 340918) to M.Á.M.-G., the Recercaixa grant to J.S.-S. (2013ACUP00194), grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, and PI0137/2018), a grant from the Generalitat Valenciana (PROMETEO/2017/017), a SEMERGEN grant, a CICYT grant provided by the Ministerio de Ciencia, Innovación y Universidades (AGL2016-75329-R), and funds from the European Regional Development Fund (CB06/03). Food companies Hojiblanca (Lucena, Spain) and Patrimonio Comunal Olivarero (Madrid, Spain) donated extra virgin olive oil for the PTREDIMED-Plus study, and the Almond Board of California (Modesto, CA, USA), American Pistachio Growers (Fresno, CA, USA), and Paramount Farms (Wonderful Company, LLC, Los Angeles, CA, USA) donated nuts for the PREDIMED-Plus pilot study. J.K. supported with Juan de la Cierva-Incorporación research grant (IJC2019-042420-I) of the Spanish Ministry of Economy, Industry and Competitiveness and European Social Funds. This call was co-financed at 50% with charge to the Operational Program FSE 2014-2020 of the Balearic Islands. J.S.-S, senior author of this article, was partially supported by ICREA under the ICREA Academia programme. | |
dc.description.abstract | Previous studies suggested that dietary polyphenols could reduce the incidence and complications of type-2 diabetes (T2D); although the evidence is still limited and inconsistent. This work analyzes whether changing to a diet with a higher polyphenolic content is associated with an improved glucose profile. At baseline, and at 1 year of follow-up visits, 5921 participants (mean age 65.0 ± 4.9, 48.2% women) who had overweight/obesity and metabolic syndrome filled out a validated 143-item semi-quantitative food frequency questionnaire (FFQ), from which polyphenol intakes were calculated. Energy-adjusted total polyphenols and subclasses were categorized in tertiles of changes. Linear mixed-effect models with random intercepts (the recruitment centers) were used to assess associations between changes in polyphenol subclasses intake and 1-year plasma glucose or glycosylated hemoglobin (HbA1c) levels. Increments in total polyphenol intake and some classes were inversely associated with better glucose levels and HbA1c after one year of follow-up. These associations were modified when the analyses were run considering diabetes status separately. To our knowledge, this is the first study to assess the relationship between changes in the intake of all polyphenolic groups and T2D-related parameters in a senior population with T2D or at high-risk of developing T2D. | |
dc.description.department | Depto. de Medicina | |
dc.description.faculty | Fac. de Medicina | |
dc.description.refereed | TRUE | |
dc.description.sponsorship | Unión Europea | |
dc.description.sponsorship | Consejo Europeo de Investigación | |
dc.description.sponsorship | Ministerio de Ciencia y Innovación (España) | |
dc.description.sponsorship | Ministerio de Economía e Industria (España) | |
dc.description.sponsorship | Junta de Andalucía. Consejería de Salud | |
dc.description.sponsorship | Generalitat Valenciana | |
dc.description.sponsorship | Gobierno de Islas Baleares | |
dc.description.sponsorship | Instituto de Salud Carlos III | |
dc.description.sponsorship | Recercaixa | |
dc.description.sponsorship | ICREA | |
dc.description.sponsorship | PREDIMED-Plus | |
dc.description.sponsorship | CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn) | |
dc.description.status | pub | |
dc.eprint.id | https://eprints.ucm.es/id/eprint/77662 | |
dc.identifier.doi | 10.3390/antiox11020316 | |
dc.identifier.issn | 2076-3921 | |
dc.identifier.officialurl | https://doi.org/10.3390/antiox11020316 | |
dc.identifier.relatedurl | https://www.mdpi.com/2076-3921/11/2/316 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14352/73289 | |
dc.issue.number | 2 | |
dc.journal.title | Antioxidants | |
dc.language.iso | eng | |
dc.page.initial | 316 | |
dc.publisher | MDPI | |
dc.relation.projectID | FEDER | |
dc.relation.projectID | Advanced Research Grant 2014–2019, 340918 | |
dc.relation.projectID | AGL2016-75329-R | |
dc.relation.projectID | Juan de la Cierva (IJC2019-042420-I) | |
dc.relation.projectID | PI0458/2013, PS0358/2016, and PI0137/2018 | |
dc.relation.projectID | PROMETEO/2017/017 | |
dc.relation.projectID | FSE 2014-2020 | |
dc.relation.projectID | Fondo de Investigación para la Salud (FIS): PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01 | |
dc.relation.projectID | Recercaixa | |
dc.relation.projectID | ICREA Academia programme | |
dc.rights | Atribución 3.0 España | |
dc.rights.accessRights | open access | |
dc.rights.uri | https://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject.cdu | 616.153.284.4 | |
dc.subject.cdu | 616.4 | |
dc.subject.keyword | Antioxidants | |
dc.subject.keyword | Mediterranean diet | |
dc.subject.keyword | Flavonoids | |
dc.subject.keyword | Phenolic acids | |
dc.subject.keyword | Obesity | |
dc.subject.keyword | Glucose | |
dc.subject.keyword | HbA1c | |
dc.subject.keyword | Glycosylated hemoglobin | |
dc.subject.keyword | Metabolic syndrome | |
dc.subject.ucm | Medicina | |
dc.subject.ucm | Dietética y nutrición (Medicina) | |
dc.subject.ucm | Endocrinología | |
dc.subject.unesco | 32 Ciencias Médicas | |
dc.subject.unesco | 3206 Ciencias de la Nutrición | |
dc.subject.unesco | 3205.02 Endocrinología | |
dc.title | Adopting a High-Polyphenolic Diet Is Associated with an Improved Glucose Profile: Prospective Analysis within the PREDIMED-Plus Trial | |
dc.type | journal article | |
dc.volume.number | 11 | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 066f66b1-aba0-451a-91f0-7e34a3b92cee | |
relation.isAuthorOfPublication.latestForDiscovery | 066f66b1-aba0-451a-91f0-7e34a3b92cee |
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