Adopting a High-Polyphenolic Diet Is Associated with an Improved Glucose Profile: Prospective Analysis within the PREDIMED-Plus Trial

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dc.contributor.authorTresserra Rimbau, Anna
dc.contributor.authorCastro Barquero, Sara
dc.contributor.authorBecerra Tomás, Nerea
dc.contributor.authorBabio, Nancy
dc.contributor.authorMartínez González, Miguel Ángel
dc.contributor.authorCorella, Dolores
dc.contributor.authorFitó, Montserrat
dc.contributor.authorRomaguera, Dora
dc.contributor.authorVioque, Jesús
dc.contributor.authorAlonso Gómez, Ángel M.
dc.contributor.authorWärnberg, Julia
dc.contributor.authorMartínez, José Alfredo
dc.contributor.authorSerra Majem, Luís
dc.contributor.authorEstruch, Ramon
dc.contributor.authorTinahones, Francisco J.
dc.contributor.authorLapetra, José
dc.contributor.authorPintó, Xavier
dc.contributor.authorTur, Josep A.
dc.contributor.authorLópez Miranda, José
dc.contributor.authorCano Ibáñez, Naomi
dc.contributor.authorDelgado Rodríguez, Miguel
dc.contributor.authorMatía Martín, Pilar
dc.contributor.authorDaimiel, Lidia
dc.contributor.authorMartín Sánchez, Vicente
dc.contributor.authorVidal, Josep
dc.contributor.authorVázquez, Clotilde
dc.contributor.authorRos, Emilio
dc.contributor.authorBasterra, Francisco Javier
dc.contributor.authorFernández de la Puente, María
dc.contributor.authorAsensio, Eva María
dc.contributor.authorCastañer, Olga
dc.contributor.authorBullón Vela, Vanessa
dc.contributor.authorTojal Sierra, Lucas
dc.contributor.authorGómez Gracia, Enrique
dc.contributor.authorCases Pérez, Eugenio
dc.contributor.authorKonieczna, Jadwiga
dc.contributor.authorGarcía Ríos, Antonio
dc.contributor.authorCasañas Quintana, Tamara
dc.contributor.authorBernal López, María Rosa
dc.contributor.authorSantos Lozano, José Manuel
dc.contributor.authorEsteve Luque, Virginia
dc.contributor.authorBouzas, Cristina
dc.contributor.authorVázquez Ruiz, Zenaida
dc.contributor.authorPalau Galindo, Antoni
dc.contributor.authorBarragan, Rocio
dc.contributor.authorLópez Grau, Mercè
dc.contributor.authorRazquín, Cristina
dc.contributor.authorGoicolea Güemez, Leire
dc.contributor.authorToledo, Estefanía
dc.contributor.authorVergaz, Manel Vila
dc.contributor.authorLamuela Raventós, Rosa María
dc.contributor.authorSalas Salvadó, Jordi
dc.date.accessioned2023-06-22T12:53:02Z
dc.date.available2023-06-22T12:53:02Z
dc.date.issued2022-02-01
dc.descriptionThe PREDIMED-Plus trial was supported by the Spanish Institutions for funding scientific biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (six coordinated Fondo de Investigaciones Sanitarias projects leaded by J.S.-S. and J.V. (Josep Vidal), including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, PI20/01158)), the Especial Action Project entitled Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus grant to J.S.-S., European Research Council (Advanced Research Grant 2014–2019, 340918) to M.Á.M.-G., the Recercaixa grant to J.S.-S. (2013ACUP00194), grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, and PI0137/2018), a grant from the Generalitat Valenciana (PROMETEO/2017/017), a SEMERGEN grant, a CICYT grant provided by the Ministerio de Ciencia, Innovación y Universidades (AGL2016-75329-R), and funds from the European Regional Development Fund (CB06/03). Food companies Hojiblanca (Lucena, Spain) and Patrimonio Comunal Olivarero (Madrid, Spain) donated extra virgin olive oil for the PTREDIMED-Plus study, and the Almond Board of California (Modesto, CA, USA), American Pistachio Growers (Fresno, CA, USA), and Paramount Farms (Wonderful Company, LLC, Los Angeles, CA, USA) donated nuts for the PREDIMED-Plus pilot study. J.K. supported with Juan de la Cierva-Incorporación research grant (IJC2019-042420-I) of the Spanish Ministry of Economy, Industry and Competitiveness and European Social Funds. This call was co-financed at 50% with charge to the Operational Program FSE 2014-2020 of the Balearic Islands. J.S.-S, senior author of this article, was partially supported by ICREA under the ICREA Academia programme.
dc.description.abstractPrevious studies suggested that dietary polyphenols could reduce the incidence and complications of type-2 diabetes (T2D); although the evidence is still limited and inconsistent. This work analyzes whether changing to a diet with a higher polyphenolic content is associated with an improved glucose profile. At baseline, and at 1 year of follow-up visits, 5921 participants (mean age 65.0 ± 4.9, 48.2% women) who had overweight/obesity and metabolic syndrome filled out a validated 143-item semi-quantitative food frequency questionnaire (FFQ), from which polyphenol intakes were calculated. Energy-adjusted total polyphenols and subclasses were categorized in tertiles of changes. Linear mixed-effect models with random intercepts (the recruitment centers) were used to assess associations between changes in polyphenol subclasses intake and 1-year plasma glucose or glycosylated hemoglobin (HbA1c) levels. Increments in total polyphenol intake and some classes were inversely associated with better glucose levels and HbA1c after one year of follow-up. These associations were modified when the analyses were run considering diabetes status separately. To our knowledge, this is the first study to assess the relationship between changes in the intake of all polyphenolic groups and T2D-related parameters in a senior population with T2D or at high-risk of developing T2D.
dc.description.departmentDepto. de Medicina
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipUnión Europea
dc.description.sponsorshipConsejo Europeo de Investigación
dc.description.sponsorshipMinisterio de Ciencia y Innovación (España)
dc.description.sponsorshipMinisterio de Economía e Industria (España)
dc.description.sponsorshipJunta de Andalucía. Consejería de Salud
dc.description.sponsorshipGeneralitat Valenciana
dc.description.sponsorshipGobierno de Islas Baleares
dc.description.sponsorshipInstituto de Salud Carlos III
dc.description.sponsorshipRecercaixa
dc.description.sponsorshipICREA
dc.description.sponsorshipPREDIMED-Plus
dc.description.sponsorshipCIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn)
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/77662
dc.identifier.doi10.3390/antiox11020316
dc.identifier.issn2076-3921
dc.identifier.officialurlhttps://doi.org/10.3390/antiox11020316
dc.identifier.relatedurlhttps://www.mdpi.com/2076-3921/11/2/316
dc.identifier.urihttps://hdl.handle.net/20.500.14352/73289
dc.issue.number2
dc.journal.titleAntioxidants
dc.language.isoeng
dc.page.initial316
dc.publisherMDPI
dc.relation.projectIDFEDER
dc.relation.projectIDAdvanced Research Grant 2014–2019, 340918
dc.relation.projectIDAGL2016-75329-R
dc.relation.projectIDJuan de la Cierva (IJC2019-042420-I)
dc.relation.projectIDPI0458/2013, PS0358/2016, and PI0137/2018
dc.relation.projectIDPROMETEO/2017/017
dc.relation.projectIDFSE 2014-2020
dc.relation.projectIDFondo de Investigación para la Salud (FIS): PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01
dc.relation.projectIDRecercaixa
dc.relation.projectIDICREA Academia programme
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.cdu616.153.284.4
dc.subject.cdu616.4
dc.subject.keywordAntioxidants
dc.subject.keywordMediterranean diet
dc.subject.keywordFlavonoids
dc.subject.keywordPhenolic acids
dc.subject.keywordObesity
dc.subject.keywordGlucose
dc.subject.keywordHbA1c
dc.subject.keywordGlycosylated hemoglobin
dc.subject.keywordMetabolic syndrome
dc.subject.ucmMedicina
dc.subject.ucmDietética y nutrición (Medicina)
dc.subject.ucmEndocrinología
dc.subject.unesco32 Ciencias Médicas
dc.subject.unesco3206 Ciencias de la Nutrición
dc.subject.unesco3205.02 Endocrinología
dc.titleAdopting a High-Polyphenolic Diet Is Associated with an Improved Glucose Profile: Prospective Analysis within the PREDIMED-Plus Trial
dc.typejournal article
dc.volume.number11
dspace.entity.typePublication
relation.isAuthorOfPublication066f66b1-aba0-451a-91f0-7e34a3b92cee
relation.isAuthorOfPublication.latestForDiscovery066f66b1-aba0-451a-91f0-7e34a3b92cee
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