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Altered expression of P2Y2 and P2X7 purinergic receptors in the isolated rat heart mediates ischemia-reperfusion injury

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dc.contributor.authorMontoya Miñano, Juan José
dc.contributor.authorGranado, Miriam
dc.contributor.authorAmor, Sara
dc.contributor.authorMonge, Luis
dc.contributor.authorFernández, Nuria
dc.contributor.authorGarcía-Villalón, Angel Luis
dc.date.accessioned2025-01-17T13:13:02Z
dc.date.available2025-01-17T13:13:02Z
dc.date.issued2015-06-10
dc.description.abstractThe aim of this study is to analyze the expression of purinergic receptors in the heart after ischemia-reperfusion, and their possible role in ischemia-reperfusion injury. Rat hearts were perfused according to the Langendorff technique and subjected to 30. min ischemia followed by 15. min reperfusion. Ischemia-reperfusion reduced the gene expression and protein content of purinergic receptors of the P2Y2 subtype, and increased the gene expression and protein content of the P2X7 subtype. Treatment with the agonist of the P2Y2 subtype 2-thio-UTP and with the antagonist of the P2X7 subtype Brilliant Blue improved myocardial function parameters, reduced cell death and increased the myocardial expression of antiapoptotic markers after ischemia-reperfusion. These results suggest that the myocardial expression of the protective P2Y2 subtype of purinergic receptors is reduced, whereas that of the harmful subtype P2X7 subtype is increased during coronary ischemia-reperfusion. This may contribute to myocardial injury in this condition.
dc.description.departmentDepto. de Radiología, Rehabilitación y Fisioterapia
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipFondo de Investigaciones Sanitarias
dc.description.sponsorshipProyectos UAM-Banco de Santander con EEUU (Convocatoria 2013)
dc.description.statuspub
dc.identifier.citationGranado, M., Amor, S., Montoya, J. J., Monge, L., Fernández, N., & García-Villalón, Á. L. (2015). Altered expression of P2Y2 and P2X7 purinergic receptors in the isolated rat heart mediates ischemia-reperfusion injury. Vascular Pharmacology, 73, 96-103. https://doi.org/10.1016/J.VPH.2015.06.003
dc.identifier.doi10.1016/J.VPH.2015.06.003
dc.identifier.officialurlhttps://doi.org/10.1016/J.VPH.2015.06.003
dc.identifier.relatedurlhttps://pubmed.ncbi.nlm.nih.gov/33580297/
dc.identifier.relatedurlhttps://link.springer.com/article/10.1007/s00394-021-02504-4
dc.identifier.urihttps://hdl.handle.net/20.500.14352/114915
dc.journal.titleVascular Pharmacology
dc.language.isoeng
dc.page.final103
dc.page.initial96
dc.publisherScience Direct
dc.relation.projectIDPS09/00394
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu612
dc.subject.keywordIschemia–reperfusion
dc.subject.keywordPurinergic receptors,
dc.subject.keywordP2Y2
dc.subject.keywordP2X7
dc.subject.keywordLangendorff
dc.subject.ucmCiencias Biomédicas
dc.subject.unesco2411 Fisiología Humana
dc.titleAltered expression of P2Y2 and P2X7 purinergic receptors in the isolated rat heart mediates ischemia-reperfusion injury
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number73
dspace.entity.typePublication
relation.isAuthorOfPublication3cf44f81-8122-416d-b112-9ae8529e00f0
relation.isAuthorOfPublication.latestForDiscovery3cf44f81-8122-416d-b112-9ae8529e00f0

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