Prediction of perinatal survival in early‐onset fetal growth restriction: role of placental growth factor

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dc.contributor.authorRodríguez Calvo, Jesús
dc.contributor.authorVillalaín González, Cecilia
dc.contributor.authorGómez Arriaga, Paula Isabel
dc.contributor.authorQuezada Rojas, María Soledad
dc.contributor.authorHerraiz García, Ignacio
dc.contributor.authorGalindo Izquierdo, Alberto
dc.date.accessioned2024-07-12T09:53:28Z
dc.date.available2024-07-12T09:53:28Z
dc.date.issued2023-02
dc.descriptionFondos FEDER
dc.description.abstractObjective To analyze the ability to predict perinatal survival and severe neonatal morbidity of cases with early-onset fetal growth restriction (eoFGR) using maternal variables, ultrasound parameters and angiogenic markers at the time of diagnosis. Methods This was a prospective observational study in a cohort of singleton pregnancies with a diagnosis of eoFGR (< 32 weeks of gestation). At diagnosis of eoFGR, complete assessment was performed, including ultrasound examination (anatomy, biometry and Doppler assessment) and maternal serum measurement of the angiogenic biomarkers, soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF). Logistic regression models for the prediction of perinatal survival (in cases diagnosed at < 28 weeks) and severe neonatal morbidity (in all liveborn cases) were calculated. Results In total, 210 eoFGR cases were included, of which 185 (88.1%) survived perinatally. The median gestational age at diagnosis was 27 + 0 weeks. All cases diagnosed at ≥ 28 weeks survived. In cases diagnosed < 28 weeks, survivors (vs non-survivors) had a higher gestational age (26.1 vs 24.4 weeks), estimated fetal weight (EFW; 626 vs 384 g), cerebroplacental ratio (1.1 vs 0.9), PlGF (41 vs 18 pg/mL) and PlGF multiples of the median (MoM; 0.10 vs 0.06) and lower sFlt-1/PlGF ratio (129 vs 479) at the time of diagnosis (all P < 0.001). The best combination of two variables for predicting perinatal survival was provided by EFW and PlGF MoM (area under the receiver-operating-characteristics curve (AUC), 0.84 (95% CI, 0.75–0.92)). These were also the best variables for predicting severe neonatal morbidity (AUC, 0.73 (95% CI, 0.66–0.80)). Conclusions A model combining EFW and maternal serum PlGF predicts accurately perinatal survival in eoFGR cases diagnosed before 28 weeks of gestation. Prenatal prediction of severe neonatal morbidity in eoFGR cases is modest regardless of the model used. © 2022 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
dc.description.departmentDepto. de Salud Pública y Materno - Infantil
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipEuropean Commission
dc.description.sponsorshipMinisterio de Economía, Industria y Competitividad (España)
dc.description.sponsorshipInstituto de Salud Carlos III (España)
dc.description.statuspub
dc.identifier.citationRodríguez-Calvo J, Villalaín C, Gómez-Arriaga PI, Quezada MS, Herraiz I, Galindo A. Prediction of perinatal survival in early-onset fetal growth restriction: role of placental growth factor. Ultrasound Obstet Gynecol. 2023 Feb;61(2):181-190. doi: 10.1002/uog.26116.
dc.identifier.doi10.1002/uog.26116
dc.identifier.issn0960-7692
dc.identifier.issn1469-0705
dc.identifier.officialurlhttps://doi.org/10.1002/uog.26116
dc.identifier.pmid36370447
dc.identifier.relatedurlhttps://obgyn.onlinelibrary.wiley.com/doi/10.1002/uog.26116
dc.identifier.urihttps://hdl.handle.net/20.500.14352/106028
dc.issue.number2
dc.journal.titleUltrasound in Obstetrics & Gynecology
dc.language.isoeng
dc.page.final190
dc.page.initial181
dc.publisherWiley
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI13%2F02405/ES/Incorporación clínica de los biomarcadores de angiogénesis (ratio sFlt-1%2FPlGF) para la detección precoz y el seguimiento de la preeclampsia/
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu618.2
dc.subject.keywordEarly-onset
dc.subject.keywordFetal growth restriction
dc.subject.keywordFGR
dc.subject.keywordPerinatal survival
dc.subject.keywordPlGF
dc.subject.ucmCiencias Biomédicas
dc.subject.unesco32 Ciencias Médicas
dc.titlePrediction of perinatal survival in early‐onset fetal growth restriction: role of placental growth factor
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number61
dspace.entity.typePublication
relation.isAuthorOfPublication1a2a754e-62a2-48f6-901e-8645c61c78de
relation.isAuthorOfPublicationb61abd28-7a0e-4d98-aade-fc39b6528de9
relation.isAuthorOfPublication.latestForDiscoveryb61abd28-7a0e-4d98-aade-fc39b6528de9
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