Role of cellular prion protein on LTP expression in aged mice

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dc.contributor.authorMaglio, Laura E.
dc.contributor.authorMartins, Vlima R.
dc.contributor.authorIzquierdo, Iván
dc.contributor.authorRamírez, Oscar A.
dc.date.accessioned2025-12-15T09:00:51Z
dc.date.available2025-12-15T09:00:51Z
dc.date.issued2006-06-30
dc.description.abstractAbstract Cellular prion protein (PrP(c)) has been associated with some physiological functions in the last few years. In a previous paper, we have demonstrated an increased hippocampal synaptic transmission in adult mice lacking this protein. In the present study, we investigate the impact of aging on the generation and maintenance of hippocampal long-term Potentiation (LTP) in 9-month-old mice devoid of PrP(c) protein (Prnp(0/0)). We observed a lower threshold for inducing LTP in 9-month-old Prnp(0/0) mice compared to wild-type ones at the same age. The maintenance of dentate gyrus LTP was more persistent in hippocampal slices from Prnp(0/0) mice. Furthermore, the expression of mRNA for NR2A and NR2B subunits of the NMDA glutamatergic receptor in hippocampus of aged Prnp(0/0) animals showed an increase compared to the wild type. We propose that increased hippocampal glutamatergic transmission in Prnp(0/0) mice is related to the enhanced plasticity and persistence of the dentate LTP.
dc.description.departmentDepto. de Fisiología
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationMaglio, Laura E., et al. «Role of Cellular Prion Protein on LTP Expression in Aged Mice». Brain Research, vol. 1097, n.o 1, junio de 2006, pp. 11-18. https://doi.org/10.1016/j.brainres.2006.04.056.
dc.identifier.doi10.1016/j.brainres.2006.04.056
dc.identifier.officialurlhttps://doi.org/10.1016/j.brainres.2006.04.056
dc.identifier.pmid16730679
dc.identifier.relatedurlhttps://www.sciencedirect.com/science/article/pii/S0006899306011577
dc.identifier.urihttps://hdl.handle.net/20.500.14352/128907
dc.issue.number1
dc.journal.titleBrain Research
dc.language.isoeng
dc.page.final18
dc.page.initial11
dc.publisherElsevier
dc.rights.accessRightsopen access
dc.subject.cdu612
dc.subject.keywordPrpc
dc.subject.keywordNMDA receptor subunit
dc.subject.keywordLong-term potentiation longevity
dc.subject.keywordHippocampus
dc.subject.keywordDentate gyrus
dc.subject.ucmFisiología
dc.subject.unesco3209.09 Psicofarmacología
dc.titleRole of cellular prion protein on LTP expression in aged mice
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number1097
dspace.entity.typePublication

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