A new targeting agent for the selective drug delivery of nanocarriers for treating neuroblastoma

Simple item page
dc.contributor.authorVillaverde Cantizano, Gonzalo
dc.contributor.authorBaeza, Alejandro
dc.contributor.authorMelen, Gustavo J.
dc.contributor.authorAlfranc, Arantzazu
dc.contributor.authorRamírez, Manuel
dc.contributor.authorVallet Regí, María Dulce Nombre
dc.date.accessioned2024-02-02T17:27:56Z
dc.date.available2024-02-02T17:27:56Z
dc.date.issued2015
dc.description.abstractNovel targeting agents against neuroblastoma based on the meta-iodobenzylguanidine (MIBG) moiety were synthesized and biologically evaluated for nanocarrier vectorization. These compounds have been anchored on the surface of drug loaded mesoporous silica nanocarriers, resulting in the improved cellular uptake in tumoral cells. Neuroblastoma (NB) is the most frequent extracranial pediatric tumor. Advanced forms of the disease (metastatic and/or refractory) have a dismal prognosis despite the combination of chemotherapy, radiotherapy, surgery and bone narrow transplants. These treatments carry severe side effects and, in some cases, compromise the life of the patient. MIBG has been widely applied in the medical diagnosis of NB due to its affinity for tumor cells through the norepinephrine transporter (NET), which is expressed in 90% of NB tumors. The exclusive accumulation of MIBG in neuroblastoma has been widely studied; however, its properties have been never exploited as a targeting agent in nanocarrier drug delivery systems. Several structural analogues of MIBG have been prepared and attached on the surface of nanocarriers. Their selective internalization has been tested against human neuroblastoma cells, which show, in the best case, cellular uptake four times higher than that of the naked nanosystem. Furthermore, in vivo experiments showed preferential and selective accumulation and retention of the targeted nanosystem comparing with the naked and only PEGylated counterpart systems. This novel nanosystem could be easily applicable to all kinds of drug delivery nanocarriers, providing a universal tool for neuroblastoma chemotherapies that is superior to classical approaches through a novel nanosystem exclusively designed to target this terrible malignancy.eng
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.doi10.1039/c5tb00287g
dc.identifier.essn2050-7518
dc.identifier.issn2050-750X
dc.identifier.officialurlhttps://doi.org/10.1039/c5tb00287g
dc.identifier.urihttps://hdl.handle.net/20.500.14352/98471
dc.language.isoeng
dc.rights.accessRightsmetadata only access
dc.subject.ucmCiencias
dc.subject.unesco23 Química
dc.titleA new targeting agent for the selective drug delivery of nanocarriers for treating neuroblastoma
dc.typejournal article
dspace.entity.typePublication
relation.isAuthorOfPublication13785694-551d-4e51-90ca-f777965d8413
relation.isAuthorOfPublication791023b8-2531-44eb-ba01-56e3b7caa0cb
relation.isAuthorOfPublication.latestForDiscovery791023b8-2531-44eb-ba01-56e3b7caa0cb
Download
Collections
Artículos