The effects of anesthetic preconditioning with sevoflurane in an experimental lung autotransplant model in pigs

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dc.contributor.authorCasanova, Javier
dc.contributor.authorGarutti Martínez, Ignacio
dc.contributor.authorSimón Adiego, Carlos María
dc.contributor.authorGiraldez, Ana
dc.contributor.authorMartín, Beatriz
dc.contributor.authorGonzález Casaurrán, Guillermo
dc.contributor.authorAzcárate Perea, Leire
dc.contributor.authorGarcía Martín, M. Cruz
dc.contributor.authorVara Ameigeiras, Elena María
dc.date.accessioned2024-02-01T09:07:57Z
dc.date.available2024-02-01T09:07:57Z
dc.date.issued2011
dc.description.abstractBackground: Ischemia-reperfusion lung injury is doubly important in thoracic surgery because of the associated ventilation damage to 1 lung. In this study we evaluated the cytoprotective effects of sevoflurane in a pulmonary autotransplant model in pigs. Methods: Twenty Large White pigs undergoing pneumonectomy plus lung autotransplant were divided into 2 10-member groups on the basis of the anesthetic received (propofol or sevoflurane). Proinflammatory mediators, oxidative stress, nitric oxide metabolism, and hemodynamic and blood variables were measured at 5 different time points. Results: There was an increase of oxidative stress markers and proinflammatory mediators in the propofol group, whereas the hemodynamic variables were similar in both groups. Conclusions: We demonstrated that sevoflurane decreased the inflammatory response and oxidative stress in a live ischemia-reperfusion lung model.
dc.description.departmentDepto. de Farmacología y Toxicología
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipInstituto de Salud Carlos III
dc.description.sponsorshipLaboratorios Abbot
dc.description.sponsorshipSociedad española de neumología y cirugía torácica
dc.description.statuspub
dc.identifier.citationCasanova J, Garutti I, Simon C, Giraldez A, Martin B, Gonzalez G, Azcarate L, Garcia C, Vara E. The effects of anesthetic preconditioning with sevoflurane in an experimental lung autotransplant model in pigs. Anesth Analg. 2011 Oct;113(4):742-8. doi: 10.1213/ANE.0b013e3182288e01. Epub 2011 Sep 2. PMID: 21890883.
dc.identifier.doi10.1213/ANE.0b013e3182288e01
dc.identifier.issn0003-2999
dc.identifier.officialurlhttps://doi.org/10.1213/ANE.0b013e3182288e01
dc.identifier.pmid21890883
dc.identifier.relatedurlhttps://pubmed.ncbi.nlm.nih.gov/21890883/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/97492
dc.issue.number4
dc.journal.titleAnesthesia Analgesia
dc.language.isoeng
dc.page.final748
dc.page.initial742
dc.publisherInternational Anesthesia Research Society
dc.relation.projectIDPI07/0840
dc.relation.projectIDPI10/01900
dc.relation.projectIDPRIMER PROYECTO INVESTIGAR ABBOTT
dc.relation.projectIDBECA SEPAR 2006/121
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsrestricted access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu617-089.5
dc.subject.ucmCiencias Biomédicas
dc.subject.unesco24 Ciencias de la Vida
dc.titleThe effects of anesthetic preconditioning with sevoflurane in an experimental lung autotransplant model in pigs
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number113
dspace.entity.typePublication
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