Efficacy and safety of a bioadhesive gel containing propolis extract, nanovitamin C and nanovitamin E on desquamative gingivitis: a double‑blind, randomized, clinical trial

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dc.contributor.authorGonzález Serrano, José
dc.contributor.authorSerrano Valle, Julia
dc.contributor.authorSanz Alonso, Mariano
dc.contributor.authorTorres García-Denche, Jesús
dc.contributor.authorHernández Vallejo, Gonzalo
dc.contributor.authorLópez-Pintor Muñoz, Rosa María
dc.date.accessioned2023-06-22T10:55:10Z
dc.date.available2023-06-22T10:55:10Z
dc.date.issued2022-07-28
dc.descriptionCRUE-CSIC (Acuerdos Transformativos 2022)
dc.description.abstractObjectives: To evaluate the efcacy of a gel-containing propolis extract, nanovitamin C, and nanovitamin E as adjuvants to professional plaque removal on desquamative gingivitis (DG). Materials and methods: A randomized clinical trial was conducted on patients sufering DG due to mucocutaneous diseases. Patients received professional supragingival prophylaxis with oral hygiene instructions and were randomly assigned to use test or control gels as toothpaste and to apply it on DG lesions 3 times/day for 4 weeks. DG clinical score (DGCS), clinical periodontal variables, and visual analog scale (VAS) for pain and oral health impact profle (OHIP-14) were collected at baseline, 2 and 4 weeks. Results: Twenty-two patients were randomly assigned to test (n=11) or control group (n=11). Eighteen had diagnosis of oral lichen planus and four of mucous membrane pemphigoid. DGCS statistically decreased in both groups after treatment with no signifcant diferences between groups. Clinical periodontal outcomes decreased in both groups, but no signifcant diferences were observed. Periodontal variables statistically improved only in test group after treatment. VAS and OHIP-14 scores decreased in test and control groups without signifcant diferences. However, only one test group showed a statistically signifcant decrease in VAS and OHIP-14 scores after treatment. No adverse efects were reported. Conclusions: Test gel may alleviate DG and improve quality of life without side efects. Clinical relevance: A gel-containing propolis extract, nanovitamin C, and nanovitamin E as adjuvants to mechanical debridement may improve both clinical and patient related outcomes in DG patients without side efects. Clinical trial registration. The study protocol was registered at clinicaltrials.gov with the following number: NCT05124366 on October 16, 2021.
dc.description.departmentDepto. de Especialidades Clínicas Odontológicas
dc.description.facultyFac. de Odontología
dc.description.refereedTRUE
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/74117
dc.identifier.doi10.1007/s00784-022-04653-0
dc.identifier.issn1436-3771
dc.identifier.officialurlhttps://doi.org/10.1007/s00784-022-04653-0
dc.identifier.urihttps://hdl.handle.net/20.500.14352/71887
dc.journal.titleClinical Oral Investigations
dc.language.isoeng
dc.publisherSpringer Nature
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.keywordDesquamative gingivitis
dc.subject.keywordOral lichen planus
dc.subject.keywordMucous membrane pemphigoid
dc.subject.keywordPropolis
dc.subject.keywordAntioxidants
dc.subject.ucmPeriodoncia
dc.subject.unesco3213.13 Ortodoncia-Estomatología
dc.titleEfficacy and safety of a bioadhesive gel containing propolis extract, nanovitamin C and nanovitamin E on desquamative gingivitis: a double‑blind, randomized, clinical trial
dc.typejournal article
dspace.entity.typePublication
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