The Microbiota of the Human Mammary Ecosystem

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dc.contributor.authorFernández Álvarez, Leonides
dc.contributor.authorPannaraj, Pia S.
dc.contributor.authorRautava, Samuli
dc.contributor.authorRodríguez Gómez, Juan Miguel
dc.date.accessioned2024-02-08T17:13:52Z
dc.date.available2024-02-08T17:13:52Z
dc.date.issued2020-11-20
dc.description.abstractHuman milk contains a dynamic and complex site-specific microbiome, which is not assembled in an aleatory way, formed by organized microbial consortia and networks. Presence of some genera, such as Staphylococcus, Streptococcus, Corynebacterium, Cutibacterium (formerly known as Propionibacterium), Lactobacillus, Lactococcus and Bifidobacterium, has been detected by both culture-dependent and culture-independent approaches. DNA from some gut-associated strict anaerobes has also been repeatedly found and some studies have revealed the presence of cells and/or nucleic acids from viruses, archaea, fungi and protozoa in human milk. Colostrum and milk microbes are transmitted to the infant and, therefore, they are among the first colonizers of the human gut. Still, the significance of human milk microbes in infant gut colonization remains an open question. Clinical studies trying to elucidate the question are confounded by the profound impact of non-microbial human milk components to intestinal microecology. Modifications in the microbiota of human milk may have biological consequences for infant colonization, metabolism, immune and neuroendocrine development, and for mammary health. However, the factors driving differences in the composition of the human milk microbiome remain poorly known. In addition to colostrum and milk, breast tissue in lactating and non-lactating women may also contain a microbiota, with implications in the pathogenesis of breast cancer and in some of the adverse outcomes associated with breast implants. This and other open issues, such as the origin of the human milk microbiome, and the current limitations and future prospects are addressed in this review.
dc.description.departmentDepto. de Farmacia Galénica y Tecnología Alimentaria
dc.description.departmentDepto. de Nutrición y Ciencia de los Alimentos
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.sponsorshipMINECO
dc.description.statuspub
dc.identifier.citationFernández L, Pannaraj PS, Rautava S and Rodríguez JM (2020) The Microbiota of the Human Mammary Ecosystem. Front. Cell. Infect. Microbiol. 10:586667. doi: 10.3389/fcimb.2020.586667
dc.identifier.doi10.3389/fcimb.2020.586667
dc.identifier.essn2235-2988
dc.identifier.officialurlhttps://www.frontiersin.org/articles/10.3389/fcimb.2020.586667/full
dc.identifier.pmid33330129
dc.identifier.relatedurlhttps://pubmed.ncbi.nlm.nih.gov/33330129/
dc.identifier.relatedurlhttps://helda.helsinki.fi/server/api/core/bitstreams/55876067-fbe7-4794-a50f-64d2dabb8fe2/content
dc.identifier.urihttps://hdl.handle.net/20.500.14352/100577
dc.journal.titleFrontiers in Cellular and Infection Microbiology
dc.language.isoeng
dc.page.initial586667
dc.publisherFrontiers
dc.relation.projectIDPID2019-105606RB-I00
dc.relation.projectIDR01 HD100542-01
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu618
dc.subject.keywordhuman milk
dc.subject.keywordmicrobiota
dc.subject.keywordmicrobiome
dc.subject.keywordvertical transfer
dc.subject.keywordbiological functions
dc.subject.keywordmastitis
dc.subject.keywordbreast tissue
dc.subject.keywordbreast cancer
dc.subject.ucmCiencias Biomédicas
dc.subject.unesco2410.10 Fisiología Humana
dc.subject.unesco3309.90 Microbiología de Alimentos
dc.titleThe Microbiota of the Human Mammary Ecosystem
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number10
dspace.entity.typePublication
relation.isAuthorOfPublication93ac7dd4-5d4a-459d-986d-01f9a64d4fd0
relation.isAuthorOfPublication5a0ccdac-6fa4-40c7-8e77-082364812226
relation.isAuthorOfPublication.latestForDiscovery93ac7dd4-5d4a-459d-986d-01f9a64d4fd0
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