Active surveillance of antimicrobial resistance in companion animals: A pilot study in a Spanish Veterinary Teaching Hospital

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dc.contributor.authorScarpellini, Raffaele
dc.contributor.authorLeal Vélez de Mendizábal, Laura
dc.contributor.authorQuevedo Caraballo, Sergio
dc.contributor.authorBlanco Cancelo, José Luis
dc.contributor.authorGarcía Sánchez, Marta Eulalia
dc.contributor.authorPérez Sancho, Marta
dc.contributor.authorPortero Fuentes, Miriam
dc.contributor.authorPenelo Hidalgo, Silvia
dc.contributor.authorEsposito, Erika
dc.contributor.authorMondo, Elisabetta
dc.contributor.authorPiva, Silvia
dc.date.accessioned2024-04-19T16:04:02Z
dc.date.available2024-04-19T16:04:02Z
dc.date.issued2024-04-02
dc.descriptionAbbreviations: AMR, antimicrobial resistance; AMRO, antimicrobial-resistant organisms; AST, antimicrobial susceptibility testing; CDT, combination disc test; CRGNB, carbapenem-resistant gram-negative bacteria; ESBL-E, extended spectrum beta-lactamases producing Enterobacterales; ESCMID, European Society of Clinical Microbiology and Infectious Diseases; EUCAST, European Committee of Antimicrobial Suceptibility Testing; HCAI, healthcare-associated infections; MALDI-TOF, matrix-assisted laser desorption/ionization time of flight; MRS, methicillin-resistant Staphylococci; MRSA, methicillin-resistant Staphylococcus aureus; MRSP, methicillin-resistant Staphylococcus pseudintermedius; 3GCR-GNB, 3rd generation cephalosporins-resistant gram-negative bacteria; VTH, veterinary teaching hospital. Authorship contribution statement: Marta Perez Sancho: Writing – review & editing, Visualization, Validation, Project administration, Methodology, Formal analysis, Data curation. Miriam Portero Fuentes: Visualization, Resources, investigation. Jose Luis Blanco: Writing – review & editing, Visualization, Validation, Supervision, Resources, Project administration, Formal analysis, Conceptualization. Marta Eulalia Garcia: Writing – review & editing, Supervision, Resources, Project administration, Conceptualization. Laura Leal Velez De Mendizabal: ´ Writing – review & editing, Methodology, Investigation. Sergio Quevedo Caraballo: Investigation. Silvia Piva: Writing – review & editing, Validation, Supervision, Resources, Funding acquisition. Raffaele Scarpellini: Writing – review & editing, Writing – original draft, Project administration, Methodology, Investigation, Data curation, Conceptualization. Erika Esposito: Data curation, Conceptualization. Elisabetta Mondo: Visualization. Silvia Penelo: Resources, Investigation.
dc.description.abstractThe role of small animal veterinary hospitals in the onset and dissemination of antimicrobial-resistant organisms (AMROs) is still not clear, and the implementation of an internal surveillance systems is a cost-effective tool to better understand their impact. The aim of this study was to describe a pilot program of active surveillance in a Spanish Veterinary Teaching Hospital, developed to estimate the detection frequency of AMROs in the commensal flora of patients and in the environment. Surveillance was focused on Methicillin-resistant Staphylococci (MRS), third generation cephalosporins resistant gram-negative bacteria (3GCR-GNB), and carbapenems-resistant gram-negative bacteria (CR-GNB). Oral and perirectal swabs were collected in the same dogs and cats hospitalized > 48 h, at their admission and before their discharge. Out of 50 patients sampled, 24% (12/50) were carriers at admission of at least one of the three investigated AMROs. Twenty-eight percent of patients (14/50) acquired at least one AMRO during the hospital stay. MRS detection frequency at admission was 12% (6/50), while acquisition was 6% (3/50). 3GCR-GNB detection frequency was 14% at admission (7/50) and acquisition 22% (11/50), while CR-GNB detection frequency was 2% at admission (1/50) and acquisition 2% (1/50). Environmental surveillance (98 samples) showed a total detection frequency of 22.4% for MRS (22/98), 2% for 3GCR-GNB and CR-GNB (2/98). Clinical staff’ shoe soles showed high detection frequency for MRS (50%). 3GCR Escherichia coli was the most isolated species in patients (n = 17). The results show how active surveillance can be used as a tool to assess the impact of AMROs in veterinary hospitals to subsequently build up tailored control plans based on specific issues.
dc.description.departmentDepto. de Sanidad Animal
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.doi10.1016/j.cimid.2024.102169
dc.identifier.essn1878-1667
dc.identifier.issn0147-9571
dc.identifier.officialurlhttps://doi.org/10.1016/j.cimid.2024.102169
dc.identifier.urihttps://hdl.handle.net/20.500.14352/103273
dc.issue.number102169
dc.journal.titleComparative Immunology, Microbiology and Infectious Diseases
dc.language.isoeng
dc.publisherElsevier
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu636.09
dc.subject.keywordAntimicrobial resistance
dc.subject.keywordCompanion animals
dc.subject.keywordEnvironmental surveillance
dc.subject.keywordCarbapenem resistance
dc.subject.keywordActive surveillance
dc.subject.ucmVeterinaria
dc.subject.unesco3109 Ciencias Veterinarias
dc.titleActive surveillance of antimicrobial resistance in companion animals: A pilot study in a Spanish Veterinary Teaching Hospital
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number108
dspace.entity.typePublication
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