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Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease

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dc.contributor.authorBurillo Maldonado, Jesús
dc.contributor.authorMarqués, Patricia
dc.contributor.authorJiménez, Beatriz
dc.contributor.authorGonzález-Blanco, Carlos
dc.contributor.authorBenito De Las Heras, Manuel R.
dc.contributor.authorGuillén Viejo, Carlos
dc.date.accessioned2025-01-09T12:05:49Z
dc.date.available2025-01-09T12:05:49Z
dc.date.issued2021-05-18
dc.description.abstractType 2 diabetes mellitus is a progressive disease that is characterized by the appearance of insulin resistance. The term insulin resistance is very wide and could affect different proteins involved in insulin signaling, as well as other mechanisms. In this review, we have analyzed the main molecular mechanisms that could be involved in the connection between type 2 diabetes and neurodegeneration, in general, and more specifically with the appearance of Alzheimer's disease. We have studied, in more detail, the different processes involved, such as inflammation, endoplasmic reticulum stress, autophagy, and mitochondrial dysfunction.
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia e Innovación
dc.description.sponsorshipCentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)
dc.description.statuspub
dc.identifier.citationBurillo, Jesús, et al. «Insulin Resistance and Diabetes Mellitus in Alzheimer’s Disease». Cells, vol. 10, n.o 5, mayo de 2021, p. 1236. DOI.org (Crossref), https://doi.org/10.3390/cells10051236.
dc.identifier.doi10.3390/cells10051236
dc.identifier.officialurlhttps://dx.doi.org/10.3390/cells10051236
dc.identifier.relatedurlhttps://pubmed.ncbi.nlm.nih.gov/34069890/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/113497
dc.journal.titleCells
dc.language.isoeng
dc.relation.projectIDSAF 2017-82133-R
dc.relation.projectIDMOIR2-CM B2017/BMB-3684
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu577.1
dc.subject.cdu577.2
dc.subject.keywordinsulin resistance
dc.subject.keywordT3DM
dc.subject.keywordER stress
dc.subject.keywordautophagy
dc.subject.keywordinflammation
dc.subject.keywordmTOR
dc.subject.ucmBiología molecular (Farmacia)
dc.subject.ucmBioquímica (Farmacia)
dc.subject.unesco2403 Bioquímica
dc.titleInsulin Resistance and Diabetes Mellitus in Alzheimer's Disease
dc.typejournal article
dc.type.hasVersionVoR
dspace.entity.typePublication
relation.isAuthorOfPublication1f9e5ae0-9499-4cba-a8d8-600cf0f27d2a
relation.isAuthorOfPublication6a240551-5797-4599-8d91-76bc38fecf8d
relation.isAuthorOfPublication55da4617-166b-44ad-be74-7d1810b876e7
relation.isAuthorOfPublication.latestForDiscovery1f9e5ae0-9499-4cba-a8d8-600cf0f27d2a

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