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Reelin plasma levels identify cognitive decline in alcohol use disorder patients during early abstinence: the influence of APOE4 expression

dc.contributor.authorEscudero Moreno, Berta
dc.contributor.authorMoya Montes, Marta
dc.contributor.authorLópez Valencia, Leticia
dc.contributor.authorArias Horcajadas, Francisco
dc.contributor.authorOrio Ortiz, Laura
dc.date.accessioned2023-09-22T13:15:20Z
dc.date.available2023-09-22T13:15:20Z
dc.date.issued2023-06-23
dc.description.abstractBackground: Apolipoprotein E (APOE)-4 isoform, reelin, and clusterin share very–low-density liporeceptor and apolipoprotein E receptor 2 receptors and are related to cognition in neuropsychiatric disorders. These proteins are expressed in plasma and brain, but studies involving plasma expression and cognition are scarce. Methods: We studied the peripheral expression (plasma and peripheral blood mononuclear cells) of these proteins in 24 middle-aged patients with alcohol use disorder (AUD) diagnosed at 4 to 12 weeks of abstinence (t = 0) and 34 controls. Cognition was assessed using the Test of Detection of Cognitive Impairment in Alcoholism. In a follow-up study (t = 1), we measured reelin levels and evaluated cognitive improvement at 6 months of abstinence. Results: APOE4 isoform was present in 37.5% and 58.8% of patients and controls, respectively, reaching similar plasma levels in ε4 carriers regardless of whether they were patients with AUD or controls. Plasma reelin and clusterin were higher in the AUD group, and reelin levels peaked in patients expressing APOE4 (P < .05, η2 = 0.09), who showed reduced very–low-density liporeceptor and apolipoprotein E receptor 2 expression in peripheral blood mononuclear cells. APOE4 had a negative effect on memory/learning mainly in the AUD group (P < .01, η2 = 0.15). Multivariate logistic regression analyses identified plasma reelin as a good indicator of AUD cognitive impairment at t = 0. At t = 1, patients with AUD showed lower reelin levels vs controls along with some cognitive improvement. Conclusions: Reelin plasma levels are elevated during early abstinence in patients with AUD who express the APOE4 isoform, identifying cognitive deterioration to a great extent, and it may participate as a homeostatic signal for cognitive recovery in the long term.
dc.description.departmentDepto. de Psicobiología y Metodología en Ciencias del Comportamiento
dc.description.facultyFac. de Psicología
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.doi10.1093/ijnp/pyad034
dc.identifier.officialurlhttps://academic.oup.com/ijnp/article/26/8/545/7205721?login=false
dc.identifier.urihttps://hdl.handle.net/20.500.14352/87885
dc.issue.number8
dc.journal.titleInternational Journal of Neuropsychopharmacology
dc.language.isoeng
dc.page.final556
dc.page.initial545
dc.publisherOxford Academic
dc.rightsAttribution-NonCommercial 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subject.keywordAlcohol use disorder
dc.subject.keywordAPOE4
dc.subject.keywordClusterin
dc.subject.keywordCognition
dc.subject.keywordReelin
dc.subject.ucmCiencias Biomédicas
dc.subject.unesco6113 Psicofarmacología
dc.subject.unesco2411 Fisiología Humana
dc.titleReelin plasma levels identify cognitive decline in alcohol use disorder patients during early abstinence: the influence of APOE4 expression
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number26
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery9bb35f9c-99ae-4acf-9df4-94bfd6140406

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