Force-extension curves for biomolecules
dc.conference.date | June 9-12 | |
dc.conference.place | Philadelphia | |
dc.conference.title | 2013 SIAM Conference on Mathematical Aspects of Materials Science | |
dc.contributor.author | Carpio Rodríguez, Ana María | |
dc.contributor.author | Bonilla, Luis L. | |
dc.contributor.author | Prados, Antonio | |
dc.date.accessioned | 2023-06-19T16:04:59Z | |
dc.date.available | 2023-06-19T16:04:59Z | |
dc.date.issued | 2013-06 | |
dc.description.abstract | Single-molecule atomic force spectroscopy probes elastic properties of proteins such as titin and ubiquitin. We analyze bioprotein folding dynamics under both force and length-clamp conditions by modeling polyprotein modules as particles in a bistable potential, connected by harmonic springs. The study of multistable equilibria in these models explains recorded sawtooth force-extension curves. We show that bifurcations and transitions through quasi-stationary domain configurations modified by thermal noise are involved in observed stepwise and abrupt refolding and unfolding phenomena under force-clamp conditions. These predictions agree with experimental observations. | en |
dc.description.department | Depto. de Análisis Matemático y Matemática Aplicada | |
dc.description.faculty | Fac. de Ciencias Matemáticas | |
dc.description.refereed | TRUE | |
dc.description.status | pub | |
dc.eprint.id | https://eprints.ucm.es/id/eprint/74487 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14352/36189 | |
dc.language.iso | eng | |
dc.rights.accessRights | open access | |
dc.subject.cdu | 51:57 | |
dc.subject.ucm | Física-Modelos matemáticos | |
dc.subject.ucm | Biomatemáticas | |
dc.subject.unesco | 2404 Biomatemáticas | |
dc.title | Force-extension curves for biomolecules | en |
dc.type | conference paper | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | f301b87d-970b-4da8-9373-fef22632392a | |
relation.isAuthorOfPublication.latestForDiscovery | f301b87d-970b-4da8-9373-fef22632392a |
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