Publication: Force-extension curves for biomolecules
dc.conference.date | June 9-12 | |
dc.conference.place | Philadelphia | |
dc.conference.title | 2013 SIAM Conference on Mathematical Aspects of Materials Science | |
dc.contributor.author | Carpio, Ana | |
dc.contributor.author | Bonilla, Luis | |
dc.contributor.author | Prados, Antonio | |
dc.date.accessioned | 2023-06-19T16:04:59Z | |
dc.date.available | 2023-06-19T16:04:59Z | |
dc.date.issued | 2013-06 | |
dc.description.abstract | Single-molecule atomic force spectroscopy probes elastic properties of proteins such as titin and ubiquitin. We analyze bioprotein folding dynamics under both force and length-clamp conditions by modeling polyprotein modules as particles in a bistable potential, connected by harmonic springs. The study of multistable equilibria in these models explains recorded sawtooth force-extension curves. We show that bifurcations and transitions through quasi-stationary domain configurations modified by thermal noise are involved in observed stepwise and abrupt refolding and unfolding phenomena under force-clamp conditions. These predictions agree with experimental observations. | |
dc.description.department | Depto. de Análisis Matemático y Matemática Aplicada | |
dc.description.faculty | Fac. de Ciencias Matemáticas | |
dc.description.refereed | TRUE | |
dc.description.status | pub | |
dc.eprint.id | https://eprints.ucm.es/id/eprint/74487 | |
dc.identifier.citation | [1] L.L. Bonilla, A. Carpio, A. Prados, Protein unfolding and refolding as transitions through virtual states, EPL (Europhysics Letters) 108, 28002, 2014 [2] A. Prados, A. Carpio, L.L. Bonilla, Sawtooth patterns in force-extension curves of biomolecules: an equilibrium-statistical-mechanics theory, Physical Review E 88, 012704, 2013 [3] A. Prados, A. Carpio, L.L. Bonilla, Spin-oscillator model for the unzipping of biomolecules by mechanical force, Physical Review E 86, 021919, 2012 [4] A. Carpio, LL Bonilla, Wave front depinning transition in discrete one-dimensional reaction-diffusion systems, Physical Review Letters 86, 6034-6037, 2001 [5] Effects of disorder on the wave front depinning transition in spatially discrete systems, A. Carpio, L.L. Bonilla, A. Luzon, Physical Review E 65, 035207, 2002 [6] A. Carpio, L.L. Bonilla, Depinning transitions in discrete reaction-diffusion equations, SIAM Journal on Applied Mathematics 63, 1056-1082, 2003 [7] A. Carpio, Wave trains, self-oscillations and synchronization in discrete media, Physica D-Nonlinear Phenomena 207, 117-136, 2005 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14352/36189 | |
dc.language.iso | eng | |
dc.rights.accessRights | open access | |
dc.subject.cdu | 51:57 | |
dc.subject.ucm | Física-Modelos matemáticos | |
dc.subject.ucm | Biomatemáticas | |
dc.subject.unesco | 2404 Biomatemáticas | |
dc.title | Force-extension curves for biomolecules | |
dc.type | conference paper | |
dspace.entity.type | Publication |
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