Aviso: para depositar documentos, por favor, inicia sesión e identifícate con tu cuenta de correo institucional de la UCM con el botón MI CUENTA UCM. No emplees la opción AUTENTICACIÓN CON CONTRASEÑA
 

Force-extension curves for biomolecules

dc.conference.dateJune 9-12
dc.conference.placePhiladelphia
dc.conference.title2013 SIAM Conference on Mathematical Aspects of Materials Science
dc.contributor.authorCarpio Rodríguez, Ana María
dc.contributor.authorBonilla, Luis L.
dc.contributor.authorPrados, Antonio
dc.date.accessioned2023-06-19T16:04:59Z
dc.date.available2023-06-19T16:04:59Z
dc.date.issued2013-06
dc.description.abstractSingle-molecule atomic force spectroscopy probes elastic properties of proteins such as titin and ubiquitin. We analyze bioprotein folding dynamics under both force and length-clamp conditions by modeling polyprotein modules as particles in a bistable potential, connected by harmonic springs. The study of multistable equilibria in these models explains recorded sawtooth force-extension curves. We show that bifurcations and transitions through quasi-stationary domain configurations modified by thermal noise are involved in observed stepwise and abrupt refolding and unfolding phenomena under force-clamp conditions. These predictions agree with experimental observations.en
dc.description.departmentDepto. de Análisis Matemático y Matemática Aplicada
dc.description.facultyFac. de Ciencias Matemáticas
dc.description.refereedTRUE
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/74487
dc.identifier.urihttps://hdl.handle.net/20.500.14352/36189
dc.language.isoeng
dc.rights.accessRightsopen access
dc.subject.cdu51:57
dc.subject.ucmFísica-Modelos matemáticos
dc.subject.ucmBiomatemáticas
dc.subject.unesco2404 Biomatemáticas
dc.titleForce-extension curves for biomoleculesen
dc.typeconference paper
dspace.entity.typePublication
relation.isAuthorOfPublicationf301b87d-970b-4da8-9373-fef22632392a
relation.isAuthorOfPublication.latestForDiscoveryf301b87d-970b-4da8-9373-fef22632392a

Download

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
abstract-SIAM12_eprints2.pdf
Size:
59.01 KB
Format:
Adobe Portable Document Format