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Effect of time-dependent ibuprofen administration on the post operatory after impacted third molar extraction: a cross-over randomized controlled trial

dc.contributor.authorPérez González, Fabián
dc.contributor.authorAbusamak, Mohammad
dc.contributor.authorSáez Alcaide, Luis Miguel
dc.contributor.authorTorres García Denche, Jesús
dc.contributor.authorMarino, Faleh Ahmad Tamimi
dc.date.accessioned2023-06-22T10:55:05Z
dc.date.available2023-06-22T10:55:05Z
dc.date.issued2022-08-03
dc.descriptionCRUE-CSIC (Acuerdos Transformativos 2022)
dc.description.abstractPurpose: To evaluate time-dependent administration of ibuprofen in a lower third molar extraction model. Methods: Eleven patients requiring bilateral surgical removal of lower third molars were recruited and randomized into a blinded crossover randomized controlled trial. For 3 days after surgery, the control group was prescribed ibuprofen 400 mg every 8 h. On the other hand, the experimental group received also ibuprofen 400 mg at breakfast and lunch, replacing the dinner intake with a placebo. Pain measurements (Visual Analog Scale from 0 to 10) were recorded at baseline, 24, 48, and 72 h postoperatively. Facial swelling and trismus were also measured at baseline, 24, and 72 h postoperatively. Results: Postoperative swelling and pain perception did not show signifcative diference between the control and experimental groups at 24, 48, and 72 h. Trismus was signifcantly lower in the control group than in the experimental group at 72 h postoperatively (p=0.008). Rescue medication consumption seemed to be comparable between groups. Conclusion: Eliminating night time ibuprofen might be insignifcant for pain control after third molar extraction.en
dc.description.departmentDepto. de Especialidades Clínicas Odontológicas
dc.description.facultyFac. de Odontología
dc.description.refereedTRUE
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/74114
dc.identifier.citationPérez-González F, Abusamak M, Sáez-Alcaide LM, et al (2022) Effect of time-dependent ibuprofen administration on the post operatory after impacted third molar extraction: a cross-over randomized controlled trial. Oral Maxillofac Surg 27:699–706. https://doi.org/10.1007/s10006-022-01104-8
dc.identifier.doi10.1007/s10006-022-01104-8
dc.identifier.issn1865-1569
dc.identifier.officialurlhttps://doi.org/10.1007/s10006-022-01104-8
dc.identifier.urihttps://hdl.handle.net/20.500.14352/71885
dc.journal.titleOral and Maxillofacial Surgery
dc.language.isoeng
dc.publisherSpringer Nature
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.keywordPosology
dc.subject.keywordChronotherapy
dc.subject.keywordIbuprofen
dc.subject.keywordExtraction
dc.subject.keywordThird molar
dc.subject.ucmOdontología (Odontología)
dc.subject.ucmCirugía bucofacial
dc.subject.unesco3213.13 Ortodoncia-Estomatología
dc.titleEffect of time-dependent ibuprofen administration on the post operatory after impacted third molar extraction: a cross-over randomized controlled trialen
dc.typejournal article
dspace.entity.typePublication
relation.isAuthorOfPublication6f2c8d34-b93c-4643-baf4-05272324c197
relation.isAuthorOfPublication.latestForDiscovery6f2c8d34-b93c-4643-baf4-05272324c197

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