A novel visible light responsive nanosystem for cancer treatment
| dc.contributor.author | Martínez Carmona, Marina | |
| dc.contributor.author | Lozano Borregón, Daniel | |
| dc.contributor.author | Baeza, Alejandro | |
| dc.contributor.author | Colilla Nieto, Montserrat | |
| dc.contributor.author | Vallet Regí, María Dulce Nombre | |
| dc.date.accessioned | 2023-06-17T22:11:31Z | |
| dc.date.available | 2023-06-17T22:11:31Z | |
| dc.date.issued | 2017-09-19 | |
| dc.description.abstract | A novel singlet-oxygen sensitive drug delivery nanocarrier able to release their cargo after exposure to visible (Vis) light of a common lamp is presented. This nanodevice is based on mesoporous silica nanoparticles (MSN) decorated with porphyrin-caps grafted via reactive oxygen species (ROS)-cleavable linkages. In presence of Vis light the porphyrinnanocaps produce singlet oxygen molecules that break the sensitive-linker, which triggers pore uncapping and therefore allows the release of the entrapped cargo (topotecan, TOP). This new system takes advantage of thE non-toxicity and greater penetration capacity of Vis radiation and a double antitumor effect due to the drug release and the ROS production. In vitro tests with HOS osteosarcoma cancer cells reveal that TOP is able to be released in a controlled fashion inside the tumor cells. This research work constitutes a proof of concept that opens up promising expectations in the seeking for new alternatives for the treatment of cancer. | |
| dc.description.department | Depto. de Química en Ciencias Farmacéuticas | |
| dc.description.faculty | Fac. de Farmacia | |
| dc.description.refereed | TRUE | |
| dc.description.sponsorship | Unión Europea. H2020 | |
| dc.description.sponsorship | Ministerio de Economía y Competitividad (MINECO) | |
| dc.description.status | pub | |
| dc.eprint.id | https://eprints.ucm.es/id/eprint/45134 | |
| dc.identifier.doi | 10.1039/c7nr05050j | |
| dc.identifier.issn | 2040-3372 | |
| dc.identifier.officialurl | http://www.rsc.org/ | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14352/18195 | |
| dc.issue.number | 9 | |
| dc.journal.title | Nanoscale | |
| dc.language.iso | eng | |
| dc.page.final | 15973 | |
| dc.page.initial | 15967 | |
| dc.publisher | Royal Society of Chemistry | |
| dc.relation.projectID | VERDI (694160) | |
| dc.relation.projectID | MAT2015-64831-R | |
| dc.rights.accessRights | open access | |
| dc.subject.cdu | 546 | |
| dc.subject.cdu | 615.46 | |
| dc.subject.keyword | Cancer treatment | |
| dc.subject.keyword | Mesoporous silica nanoparticles (MSN) | |
| dc.subject.keyword | Singlet oxygen molecules | |
| dc.subject.ucm | Materiales | |
| dc.subject.ucm | Química inorgánica (Química) | |
| dc.subject.unesco | 3312 Tecnología de Materiales | |
| dc.subject.unesco | 2303 Química Inorgánica | |
| dc.title | A novel visible light responsive nanosystem for cancer treatment | |
| dc.type | journal article | |
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