Characterization of Retinal Drusen in Subjects at High Genetic Risk of Developing Sporadic Alzheimer’s Disease: An Exploratory Analysis

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dc.contributor.authorLópez Cuenca, Inés
dc.contributor.authorGarcía Martín, Elena Salobrar
dc.contributor.authorGil Salgado, Inés
dc.contributor.authorSánchez Puebla, Lídia
dc.contributor.authorElvira Hurtado, Lorena
dc.contributor.authorFernández Albarral, José Antonio
dc.contributor.authorRamírez Toraño, Federico
dc.contributor.authorBarabash, Ana
dc.contributor.authorFrutos Lucas, Jaisalmer de
dc.contributor.authorSalazar Corral, Juan José
dc.contributor.authorRamirez Sebastian, Jose Manuel
dc.contributor.authorRamírez Sebastián, Ana Isabel
dc.contributor.authorHoz Montañana, María Rosa de
dc.date.accessioned2023-06-22T10:48:09Z
dc.date.available2023-06-22T10:48:09Z
dc.date.issued2022-05-23
dc.descriptionReceived: 19 April 2022 / Revised: 17 May 2022 / Accepted: 19 May 2022 / Published: 23 May 2022
dc.description.abstractHaving a family history (FH+) of Alzheimer’s disease (AD) and being a carrier of at least one ɛ4 allele of the ApoE gene are two of the main risk factors for the development of AD. AD and age-related macular degeneration (AMD) share one of the main risk factors, such as age, and characteristics including the presence of deposits (Aβ plaques in AD and drusen in AMD); however, the role of apolipoprotein E isoforms in both pathologies is controversial. We analyzed and characterized retinal drusen by optical coherence tomography (OCT) in subjects, classifying them by their AD FH (FH- or FH+) and their allelic characterization of ApoE ɛ4 (ApoE ɛ4- or ApoE ɛ4+) and considering cardiovascular risk factors (hypercholesterolemia, hypertension, and diabetes mellitus). In addition, we analyzed the choroidal thickness by OCT and the area of the foveal avascular zone with OCTA. We did not find a relationship between a family history of AD or any of the ApoE isoforms and the presence or absence of drusen. Subjects with drusen show choroidal thinning compared to patients without drusen, and thinning could trigger changes in choroidal perfusion that may give rise to the deposits that generate drusen
dc.description.departmentUnidad Docente de Inmunología, Oftalmología y ORL
dc.description.departmentDepto. de Inmunología, Oftalmología y ORL
dc.description.facultyFac. de Óptica y Optometría
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia e Innovación (MICINN)
dc.description.sponsorshipInstituto de Salud Carlos III (ISCIII)
dc.description.sponsorshipMinisterio de Economía y Competitividad (MINECO)
dc.description.sponsorshipUniversidad Complutense de Madrid
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/73146
dc.identifier.doi10.3390/jpm12050847
dc.identifier.issn2075-4426
dc.identifier.officialurlhttps://doi.org/10.3390/jpm12050847
dc.identifier.relatedurlhttps://www.mdpi.com/2075-4426/12/5/847
dc.identifier.urihttps://hdl.handle.net/20.500.14352/71694
dc.issue.number5
dc.journal.titleJournal of Personalized Medicine
dc.language.isoeng
dc.page.initial15 p.
dc.publisherMDPI
dc.relation.projectIDRETIBRAIN (RED2018-102499-T)
dc.relation.projectIDOFTARED (RD16/0008/0005)
dc.relation.projectIDPSI2015-68793-C3-1-R
dc.relation.projectIDCT42/18-CT43/18; FPU17/01023; CT82/20-CT83/20
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.cdu616.894-053.9
dc.subject.cdu611.843.112:616.894-053.9
dc.subject.cdu611.843.112:616-073.75
dc.subject.keywordAlzheimer’s disease
dc.subject.keywordApoE ɛ4
dc.subject.keywordfamily history
dc.subject.keywordhard drusen
dc.subject.keywordOCT
dc.subject.keywordretina
dc.subject.keywordAMD
dc.subject.keywordhypercholesterolemia
dc.subject.keywordhypertension
dc.subject.keyworddiabetes mellitus
dc.subject.keywordchoroid
dc.subject.ucmNeurociencias (Medicina)
dc.subject.ucmOftalmología
dc.subject.ucmAnatomía ocular
dc.subject.ucmTécnicas de la imagen
dc.subject.unesco2490 Neurociencias
dc.subject.unesco3201.09 Oftalmología
dc.titleCharacterization of Retinal Drusen in Subjects at High Genetic Risk of Developing Sporadic Alzheimer’s Disease: An Exploratory Analysis
dc.typejournal article
dc.volume.number12
dspace.entity.typePublication
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relation.isAuthorOfPublication554437df-fa3d-41e1-862c-bcdda1dbd67a
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relation.isAuthorOfPublication.latestForDiscovery6d91551a-f52f-4428-9fd9-4e840fb364b2
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