Microbial Matryoshka: Addressing the Relationship between Pathogenic Flagellated Protozoans and Their RNA Viral Endosymbionts (Family Totiviridae).

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dc.contributor.authorIbáñez Escribano, Alexandra
dc.contributor.authorGómez Muñoz, María Teresa
dc.contributor.authorMateo Barrientos, Marta
dc.contributor.authorFonseca Berzal, Cristina Rosa
dc.contributor.authorGómez-Lucía Duato, María Esperanza
dc.contributor.authorGarcía-Pérez, Raquel
dc.contributor.authorAlunda Rodríguez, José María
dc.contributor.authorCarrión Herrero, Francisco Javier
dc.date.accessioned2024-07-23T12:41:34Z
dc.date.available2024-07-23T12:41:34Z
dc.date.issued2024-07-17
dc.description.abstractGiardiosis, trichomonosis, leishmaniosis, and trypanosomosis are parasitic diseases caused by flagellated protozoa that have a major global health impact, and their control is a priority action line in the agenda of the current One Health Program. The pathogens causing these diseases can establish an endosymbiotic relationship with RNA viruses of the Totiviridae family that can alter the course of the final infection in a mammal. To easily understand the sequence of interactions that occur between the agents involved, from a structural point of view, we can imagine a “matryoshka”-type infection model, wherein the virus represents the smallest matryoshka infecting the flagellated protozoan, which represents the medium matryoshka infecting the mammal, the largest matryoshka. In this manuscript, we will review the available information on the complications generated, such as the aggravation of pathogenesis or treatment failures, because of the established association between these flagellated pathogens and their respective endosymbiont viruses. Accurate diagnosis is required to detect these situations of endosymbiont co-infection and to be able to apply tailor-made treatments that target both the flagellated parasite and the virus that hides inside it. Taken together, these approaches will allow us to achieve and optimize appropriate sanitary control strategies.
dc.description.departmentDepto. de Microbiología y Parasitología
dc.description.facultyFac. de Farmacia
dc.description.fundingtypeDescuento UCM
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationIbañez-Escribano, Alexandra, et al. «Microbial Matryoshka: Addressing the Relationship between Pathogenic Flagellated Protozoans and Their RNA Viral Endosymbionts (Family Totiviridae)». Veterinary Sciences, vol. 11, n.o 7, julio de 2024, p. 321. DOI.org (Crossref), https://doi.org/10.3390/vetsci11070321.
dc.identifier.doi10.3390/vetsci11070321
dc.identifier.officialurlhttps://doi.org/10.3390/vetsci11070321
dc.identifier.relatedurlhttps://www.mdpi.com/2306-7381/11/7/321
dc.identifier.urihttps://hdl.handle.net/20.500.14352/107060
dc.issue.number7
dc.journal.titleVeterinary Sciences
dc.language.isoeng
dc.page.initial321
dc.publisherMDPI
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu577.1
dc.subject.cdu577.2
dc.subject.keywordTotiviridae
dc.subject.keywordGiardiavirus
dc.subject.keywordTrichomonasvirus
dc.subject.keywordLeishmaniavirus
dc.subject.keywordRNA virus
dc.subject.keywordviral endosymbiont
dc.subject.ucmCiencias Biomédicas
dc.subject.ucmBiología molecular (Farmacia)
dc.subject.ucmBioquímica (Farmacia)
dc.subject.unesco32 Ciencias Médicas
dc.titleMicrobial Matryoshka: Addressing the Relationship between Pathogenic Flagellated Protozoans and Their RNA Viral Endosymbionts (Family Totiviridae).
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number11
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