Influence of SARS-CoV-2 Status and Aging on the Nasal and Fecal Immunological Profiles of Elderly Individuals Living in Nursing Homes

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dc.contributor.authorAlba Rubio, Claudio
dc.contributor.authorMozota, Marta
dc.contributor.authorArroyo Rodríguez, Rebeca
dc.contributor.authorGómez Torres, Natalia
dc.contributor.authorCastro Navarro, Irma
dc.contributor.authorRodríguez Gómez, Juan Miguel
dc.date.accessioned2024-04-29T11:05:39Z
dc.date.available2024-04-29T11:05:39Z
dc.date.issued2023-06-20
dc.description.abstractIn the frame of SARS-CoV-2 infection, studies regarding cytokine profiling of mucosal-related samples are scarce despite being the primary infection sites. The objective of this study was to compare the nasal and fecal inflammatory profiles of elderly individuals living in a nursing home highly affected by COVID-19 (ELD1) with those of elderly individuals living in a nursing home with no cases of SARS-CoV-2 infection (ELD2) and, also, with those of healthy SARS-CoV-2-negative younger adults (YHA). BAFF/TNFSF13B, IL6, IL10 and TNF-α (immunological hallmarks of SARS-CoV-2 infection) were the only immune factors whose concentrations were different in the three groups. Their highest concentrations were achieved in the ELD1 group. Nasal and fecal concentrations of a wide number of pro-inflammatory cytokines were similar in the ELD1 and ELD2 groups but higher than those found in the YHA samples. These results reinforce the hypothesis that immunosenescence and inflammaging rendered the elderly as a highly vulnerable population to a neo-infection, such as COVID-19, which was evidenced during the first pandemic waves.
dc.description.departmentDepto. de Nutrición y Ciencia de los Alimentos
dc.description.facultyFac. de Veterinaria
dc.description.fundingtypeDescuento UCM
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.doi10.3390/v15061404
dc.identifier.issn1999-4915
dc.identifier.officialurlhttps://doi.org/10.3390/v15061404
dc.identifier.relatedurlhttps://www.mdpi.com/1999-4915/15/6/1404
dc.identifier.urihttps://hdl.handle.net/20.500.14352/103629
dc.issue.number6
dc.journal.titleViruses
dc.language.isoeng
dc.page.initial1404
dc.publisherMDPI
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.keywordElderly
dc.subject.keywordCOVID-19
dc.subject.keywordFeces
dc.subject.keywordNasal samples
dc.subject.keywordCytokines
dc.subject.keywordChemokines
dc.subject.keywordNursing home
dc.subject.keywordSARS-CoV-2
dc.subject.ucmEnfermedades infecciosas
dc.subject.ucmGeriatría
dc.subject.unesco3205.05 Enfermedades Infecciosas
dc.subject.unesco3201.07 Geriatría
dc.titleInfluence of SARS-CoV-2 Status and Aging on the Nasal and Fecal Immunological Profiles of Elderly Individuals Living in Nursing Homes
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number15
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery751dc85d-cdd9-4064-82c1-ccee5dfcbe16
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