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Schaffer-Specific Local Field Potentials Reflect Discrete Excitatory Events at Gamma Frequency That May Fire Postsynaptic Hippocampal CA1 Units

dc.contributor.authorMakarov Slizneva, Valeriy
dc.contributor.authorFernández-Ruiz, Antonio
dc.contributor.authorBenito, Nuria
dc.contributor.authorHerreras, Óscar
dc.date.accessioned2023-06-20T00:17:33Z
dc.date.available2023-06-20T00:17:33Z
dc.date.issued2012-04-11
dc.description.abstractInformation processing and exchange between brain nuclei are made through spike series sent by individual neurons in highly irregular temporal patterns. Synchronization in cell assemblies, proposed as a network language for internal neural representations, still has little experimental support. We use a novel technique to extract pathway-specific local field potentials (LFPs) in the hippocampus to explore the ongoing temporal structure of a single presynaptic input, the CA3 Schaffer pathway, and its contribution to the spontaneous output of CA1 units in anesthetized rat. We found that Schaffer-specific LFPs are composed of a regular succession of pulse-like excitatory packages initiated by spontaneous clustered firing of CA3 pyramidal cells to which individual units contribute variably. A fraction of these packages readily induce firing of CA1 pyramidal cells and interneurons, the so-called Schaffer-driven spikes, revealing the presynaptic origin in the output code of single CA1 units. The output of 70% of CA1 pyramidal neurons contains up to 10% of such spikes. Our results suggest a hierarchical internal operation of the CA3 region based on sequential oscillatory activation of pyramidal cell assemblies whose activity partly gets in the output code at the next station. We conclude that CA1 output may directly reflect the activity of specific ensembles of CA3 neurons. Thus, the fine temporal structure of pathway-specific LFPs, as an accurate readout of the activity of a presynaptic population, is useful in searching for hidden presynaptic code in irregular spikes series of individual neurons and assemblies.
dc.description.departmentDepto. de Análisis Matemático y Matemática Aplicada
dc.description.facultyFac. de Ciencias Matemáticas
dc.description.refereedTRUE
dc.description.sponsorshipSpanish Ministry of Science and Innovation
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/16698
dc.identifier.doi10.1523/JNEUROSCI.4499-11.2012
dc.identifier.issn0270-6474
dc.identifier.officialurlhttp://www.jneurosci.org/content/32/15/5165.full.pdf+html
dc.identifier.relatedurlhttp://www.jneurosci.org/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/42341
dc.issue.number15
dc.journal.titleJournal of Neuroscience
dc.page.final5176
dc.page.initial5165
dc.publisherSociety for Neuroscience
dc.relation.projectIDBFU2010-19192/BFI
dc.relation.projectIDFIS2010-20054
dc.rights.accessRightsmetadata only access
dc.subject.cdu159.964
dc.subject.keywordCurrent source-density
dc.subject.keywordIndependent component analysis
dc.subject.keywordPyramidal cells
dc.subject.keywordCortical activity
dc.subject.keywordDendritic spikes
dc.subject.keywordBehaving rat
dc.subject.keywordNetwork
dc.subject.keywordOscillations
dc.subject.keywordNeurons
dc.subject.keywordOrganization
dc.subject.ucmNeurociencias (Biológicas)
dc.subject.unesco2490 Neurociencias
dc.titleSchaffer-Specific Local Field Potentials Reflect Discrete Excitatory Events at Gamma Frequency That May Fire Postsynaptic Hippocampal CA1 Units
dc.typejournal article
dc.volume.number32
dspace.entity.typePublication
relation.isAuthorOfPublicationa5728eb3-1e14-4d59-9d6f-d7aa78f88594
relation.isAuthorOfPublication.latestForDiscoverya5728eb3-1e14-4d59-9d6f-d7aa78f88594

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