Biological effects of group IIA secreted phosholipase A2
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2002
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Wiley
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Fuentes, L., Hernández, M., Nieto, M. L., & Sánchez Crespo, M. (2002). Biological effects of group IIA secreted phosholipase A(2). FEBS letters, 531(1), 7–11. https://doi.org/10.1016/s0014-5793(02)03401-4
Abstract
Group IIA secreted phospholipase A(2) (sPLA(2)-IIA) is the most abundant element in human tissues of a large family of low molecular weight phospholipases A(2), which shows properties different from those displayed by the cytosolic phospholipase A(2) involved in the release of arachidonic acid. sPLA(2)-IIA behaves as a ligand for a group of receptors inside the C-type multilectin mannose receptor family and also interacts with heparan sulfate proteoglycans such as glypican, the dermatan/chondroitin sulfate-rich decorin, and the chondroitin sulfate-rich versican, thus being able to internalize to specific compartments within the cell and producing biological responses. This review provides a short summary of the biological actions of sPLA(2)-IIA on intracellular signaling pathways.