Lipid–protein and protein–protein interactions in the pulmonary surfactant system and their role in lung homeostasis

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dc.contributor.authorCañadas Benito, Olga
dc.contributor.authorOlmeda Lozano, Bárbara
dc.contributor.authorAlonso Eugenio, Alejandro
dc.contributor.authorPérez-Gil, Jesús
dc.date.accessioned2023-06-16T15:22:00Z
dc.date.available2023-06-16T15:22:00Z
dc.date.issued2020-05-25
dc.description.abstractPulmonary surfactant is a lipid/protein complex synthesized by the alveolar epithelium and secreted into the airspaces, where it coats and protects the large respiratory air–liquid interface. Surfactant, assembled as a complex network of membranous structures, integrates elements in charge of reducing surface tension to a minimum along the breathing cycle, thus maintaining a large surface open to gas exchange and also protecting the lung and the body from the entrance of a myriad of potentially pathogenic entities. Different molecules in the surfactant establish a multivalent crosstalk with the epithelium, the immune system and the lung microbiota, constituting a crucial platform to sustain homeostasis, under health and disease. This review summarizes some of the most important molecules and interactions within lung surfactant and how multiple lipid–protein and protein–protein interactions contribute to the proper maintenance of an operative respiratory surface.
dc.description.departmentSección Deptal. de Bioquímica y Biología Molecular (Biológicas)
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia e Innovación (MICINN)
dc.description.sponsorshipComunidad de Madrid
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/62041
dc.identifier.doi10.3390/ijms21103708
dc.identifier.issn1661-6596, ESSN 1422-0067
dc.identifier.officialurlhttps://doi.org/10.3390/ijms21103708
dc.identifier.relatedurlhttps://www.mdpi.com/1422-0067/21/10/3708
dc.identifier.urihttps://hdl.handle.net/20.500.14352/6496
dc.issue.number10
dc.journal.titleInternational Journal of Molecular Sciences
dc.language.isoeng
dc.page.final39
dc.page.initial1
dc.publisherMDPI
dc.relation.projectID(RTI2018-094564-B-I00)
dc.relation.projectIDNANOBIOCARGO-CM (P2018/NMT-4389)
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.cdu577.112
dc.subject.keywordPpulmonary surfactant film
dc.subject.keywordSurfactant metabolism
dc.subject.keywordSurface tension
dc.subject.keywordRespiratory air–liquid
dc.subject.keywordinterface Inflammation
dc.subject.keywordAantimicrobial activity
dc.subject.keywordApoptosis
dc.subject.keywordEfferocytosis
dc.subject.keywordTissue repair
dc.subject.ucmBioquímica (Biología)
dc.subject.unesco2302 Bioquímica
dc.titleLipid–protein and protein–protein interactions in the pulmonary surfactant system and their role in lung homeostasis
dc.typejournal article
dc.volume.number21
dspace.entity.typePublication
relation.isAuthorOfPublication25a89a2f-a381-4f15-9a6b-59430ee96a63
relation.isAuthorOfPublicatione68d4ff0-7009-42c2-947b-fc26729b27d9
relation.isAuthorOfPublication.latestForDiscovery25a89a2f-a381-4f15-9a6b-59430ee96a63
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