Anti-Trypanosomatidae Activity of Essential Oils and Their Main Components from Selected Medicinal Plants

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dc.contributor.authorBailén, María
dc.contributor.authorIllescas, Cristina
dc.contributor.authorQuijada, Mónica
dc.contributor.authorMartínez Díaz, Rafael Alberto
dc.contributor.authorOchoa, Eneko
dc.contributor.authorGómez Muñoz, María Teresa
dc.contributor.authorNavarro Rocha, Juliana
dc.contributor.authorGonzález Coloma, Azucena
dc.date.accessioned2023-06-22T12:47:44Z
dc.date.available2023-06-22T12:47:44Z
dc.date.issued2023-02-02
dc.description.abstractKinetoplastida is a group of flagellated protozoa characterized by the presence of a kinetoplast, a structure which is part of a large mitochondria and contains DNA. Parasites of this group include genera such as Leishmania, that cause disease in humans and animals, and Phytomonas, that are capable of infecting plants. Due to the lack of treatments, the low efficacy, or the high toxicity of the employed therapeutic agents there is a need to seek potential alternative treatments. In the present work, the antiparasitic activity on Leishmania infantum and Phytomonas davidi of 23 essential oils (EOs) from plants of the Lamiaceae and Asteraceae families, extracted by hydrodistillation (HD) at laboratory scale and steam distillation (SD) in a pilot plant, were evaluated. The chemical compositions of the EOs were determined by gas chromatography-mass spectrometry. Additionally, the cytotoxic activity on mammalian cells of the major components from the most active EOs was evaluated, and their anti-Phytomonas and anti-Leishmania effects analyzed. L. infantum was more sensitive to the EOs than P. davidi. The EOs with the best anti-kinetoplastid activity were S. montana, T. vulgaris, M. suaveolens, and L. luisieri. Steam distillation increased the linalyl acetate, β-caryophyllene, and trans-α-necrodyl acetate contents of the EOs, and decreased the amount of borneol and 1,8 cineol. The major active components of the EOs were tested, with thymol being the strongest anti-Phytomonas compound followed by carvacrol. Our study identified potential treatments against kinetoplastids.
dc.description.departmentDepto. de Sanidad Animal
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia, Innovación y Universidades (MCIU)
dc.description.sponsorshipSantander-UCM
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/77377
dc.identifier.doi10.3390/molecules28031467
dc.identifier.issn1420-3049
dc.identifier.officialurlhttps://doi.org/10.3390/molecules28031467
dc.identifier.relatedurlhttps://www.mdpi.com/1420-3049/28/3/1467
dc.identifier.urihttps://hdl.handle.net/20.500.14352/73189
dc.issue.number3
dc.journal.titleMolecules
dc.language.isoeng
dc.page.initial1467
dc.publisherMPDI
dc.relation.projectIDPID2020-114207RB-I00 and PID2019-106222RB-C31/SRA
dc.relation.projectIDPR108/20-08
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.keywordNatural products
dc.subject.keywordPhytomonas
dc.subject.keywordLeishmania
dc.subject.keywordCytotoxicity
dc.subject.keywordLamiaceae
dc.subject.keywordAsteraceae
dc.subject.keywordThymol
dc.subject.keywordCarvacrol
dc.subject.ucmBotánica (Biología)
dc.subject.unesco2417.03 Botánica General
dc.titleAnti-Trypanosomatidae Activity of Essential Oils and Their Main Components from Selected Medicinal Plants
dc.typejournal article
dc.volume.number28
dspace.entity.typePublication
relation.isAuthorOfPublication1c164bfa-b7f9-4f89-86e5-0d00deae6345
relation.isAuthorOfPublication.latestForDiscovery1c164bfa-b7f9-4f89-86e5-0d00deae6345
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