Bacterial metabolism as responsible of beneficial effects of phytoestrogens on human health

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dc.contributor.authorBravo Vázquez, Daniel Antonio
dc.contributor.authorPeirotén, Ángela
dc.contributor.authorLandete, José María
dc.contributor.editorTaylor & Francis
dc.date.accessioned2024-02-01T18:00:45Z
dc.date.available2024-02-01T18:00:45Z
dc.date.issued2019-06-04
dc.description.abstractPhytoestrogens (PE) are compounds found in plants such as soy (isoflavones), flax seeds and cereals (lignans) and pomegranates (ellagitannins). PE have shown estrogenic/antiestrogenic, antioxidant, anti-inflammatory, antineoplastic and apoptotic activities. The human studies are showing promising although inconsistent results about the beneficial effects of PE on ameliorating the menopausal symptoms or reducing the risk of certain cancers, cardiovascular disease or diabetes. The effects of PE on the organism are mediated by the intestinal microbiota, which transforms them into bioactive PE such as genistein, equol, enterolignans and certain urolithins. In this work, we review the most recent findings about the bacteria able to metabolize PE, together with the latest studies on the effects of PE on health. In addition, we describe the possible factors hindering the demonstration of the beneficial effect of PE on health, evincing the importance of measuring the actual circulating PE in order to encompass the variability of PE metabolism due to the intestinal microbiota. With this in mind, we also explore an approach to ensure the access to bioactive PE.
dc.description.departmentDepto. de Genética, Fisiología y Microbiología
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationCritical Reviews in Food Science and Nutrition 60(11): 1922–1937 (2020)
dc.identifier.doi10.1080/10408398.2019.1622505
dc.identifier.issn1040-8398
dc.identifier.officialurlhttps://doi.org/10.1080/10408398.2019.1622505
dc.identifier.urihttps://hdl.handle.net/20.500.14352/97956
dc.issue.number11
dc.journal.titleCritical Reviews in Food Science and Nutrition
dc.language.isoeng
dc.page.final1937
dc.page.initial1922
dc.publisherTaylor & Francis
dc.rights.accessRightsrestricted access
dc.subject.keywordIsoflavones Cancer Enterolignans Intestinal microbiota Menopause Urolithins
dc.subject.ucmCiencias
dc.subject.unesco24 Ciencias de la Vida
dc.titleBacterial metabolism as responsible of beneficial effects of phytoestrogens on human health
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number60
dspace.entity.typePublication
relation.isAuthorOfPublicationc2079d3a-9509-477c-9aba-1c278053fffe
relation.isAuthorOfPublication.latestForDiscoveryc2079d3a-9509-477c-9aba-1c278053fffe
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