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Carrageenan-Based Acyclovir Mucoadhesive Vaginal Tablets for Prevention of Genital Herpes

dc.contributor.authorPacheco Quito, Edisson Mauricio
dc.contributor.authorRuiz Caro, Roberto
dc.contributor.authorRubio, Juan
dc.contributor.authorTamayo, Aitana
dc.contributor.authorVeiga Ochoa, María Dolores
dc.date.accessioned2023-06-17T09:16:46Z
dc.date.available2023-06-17T09:16:46Z
dc.date.issued2020-05-11
dc.description.abstractWomen are the most affected by genital herpes, which is one of the most common sexually transmitted infections, affecting more than 400 million people worldwide. The application of vaginal microbicides could provide a safe method of protection. Acyclovir is a safe and effective medication for vaginal administration, and numerous benefits have been observed in the treatment of primary or recurrent lesions due to genital herpes. Vaginal tablets based on a combination of the polymers iota-carrageenan and hydroxypropyl methylcellulose were developed for the controlled release of acyclovir. Swelling, mucoadhesion and drug release studies were carried out in simulated vaginal fluid. The tablets, containing a combination of iota-carrageenan and hydroxypropyl methylcellulose, have an adequate uptake of the medium that allows them to develop the precise consistency and volume of gel for the controlled release of acyclovir. Its high mucoadhesive capacity also allows the formulation to remain in the vaginal area long enough to ensure the complete release of acyclovir. These promising formulations for the prevention of genital herpes deserve further evaluation.
dc.description.departmentDepto. de Farmacia Galénica y Tecnología Alimentaria
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/68531
dc.identifier.doi10.3390/md18050249
dc.identifier.issn1660-3397
dc.identifier.officialurlhttps://doi.org/10.3390/md18050249
dc.identifier.relatedurlhttps://www.mdpi.com/1660-3397/18/5/249
dc.identifier.urihttps://hdl.handle.net/20.500.14352/8525
dc.issue.number5
dc.journal.titleMarine Drugs
dc.language.isoeng
dc.page.initial249
dc.publisherhttps://www.mdpi.com/1660-3397/18/5/249
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.keywordgenital herpes
dc.subject.keywordacyclovir controlled release
dc.subject.keywordmucoadhesive vaginal tablets
dc.subject.keywordmarine polymers
dc.subject.keywordiota-carrageenan
dc.subject.keywordhydroxypropyl methylcellulose
dc.subject.ucmEnfermedades infecciosas
dc.subject.ucmBiología molecular (Farmacia)
dc.subject.ucmFarmacología (Farmacia)
dc.subject.unesco3205.05 Enfermedades Infecciosas
dc.subject.unesco3209 Farmacología
dc.titleCarrageenan-Based Acyclovir Mucoadhesive Vaginal Tablets for Prevention of Genital Herpes
dc.typejournal article
dc.volume.number18
dspace.entity.typePublication
relation.isAuthorOfPublication567bff1a-57d2-4c4f-9c25-f46e2b7d5dd3
relation.isAuthorOfPublication29bd420d-26c9-4026-b32c-14d44ef64b88
relation.isAuthorOfPublication.latestForDiscovery567bff1a-57d2-4c4f-9c25-f46e2b7d5dd3

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