Role of nerve growth factor in the reproductive physiology of female rabbits: A review

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dc.contributor.authorRebollar, P.G.
dc.contributor.authorGarcía García, Rosa María
dc.contributor.authorArias Álvarez, María
dc.contributor.authorSánchez Rodríguez, Ana
dc.contributor.authorLorenzo González, Pedro Luis
dc.date.accessioned2024-04-05T14:34:35Z
dc.date.available2024-04-05T14:34:35Z
dc.date.issued2020-01-30
dc.description.abstractRabbit does are reflex ovulators such that coitus is needed to release GnRH and elicit the LH surge that triggers the ovulation of mature oocytes. However, the mechanisms eliciting ovulation in this species remain unclear. One of the most promising recently discovered candidates with a role in female reproductive physiology is nerve growth factor beta (b-NGF). This neurotrophin and its high-affinity receptor TrkA and low affinity receptor p75, is present in all compartments of the ovary, oviduct and uterus suggesting a physiologic role in ovarian folliculogenesis, steroidogenesis, ovulation, luteogenesis and embryo development. Besides, evidence exists that b-NGF found in seminal plasma could exert a modulatory role in the female hypothalamus-pituitary-ovarian axis contributing to the adrenergic and cholinergic neuronal stimulus of GnRH neurons in an endocrine manner during natural mating. Probably, the paracrine and local roles of the neurotrophin in steroidogenesis and ovulation reinforce the neuroendocrine pathway that leads to ovulation. This review updates knowledge of the role of b-NGF in rabbit reproduction, including its possible contribution to the mechanisms of action that induce ovulation, and discusses perspectives for the future applications of this neurotrophin on rabbit farms.
dc.description.departmentDepto. de Producción Animal
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.doi10.1016/j.theriogenology.2020.01.070 Get rights and content
dc.identifier.essn1879-3231
dc.identifier.issn0093-691X
dc.identifier.urihttps://hdl.handle.net/20.500.14352/102775
dc.journal.titleTheriogenology
dc.language.isoeng
dc.page.final328
dc.page.initial321
dc.publisherElsevier
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu636.09
dc.subject.keywordNerve growth factor
dc.subject.keywordRabbit
dc.subject.keywordFemale
dc.subject.keywordOvulation
dc.subject.keywordReproductive tract
dc.subject.ucmVeterinaria
dc.subject.unesco3109 Ciencias Veterinarias
dc.titleRole of nerve growth factor in the reproductive physiology of female rabbits: A review
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number150
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery0e188779-5d5d-4ba1-bbf4-e17a29169790
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