Interference of paratuberculosis with the diagnosis of tuberculosis in a goat flock with a natural mixed infection

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dc.contributor.authorÁlvarez Sánchez, Julio
dc.contributor.authorJuan Ferré, Lucía De
dc.contributor.authorBezos Garrido, Javier
dc.contributor.authorRomero Martínez, Beatriz
dc.contributor.authorSáez, Jose Luis
dc.contributor.authorReviriego Gordejo, F.J.
dc.contributor.authorBriones Dieste, Víctor
dc.contributor.authorMoreno Romo, Miguel Ángel
dc.contributor.authorMateos García, Ana Isabel
dc.contributor.authorDomínguez Rodríguez, Lucas José
dc.contributor.authorAranaz Martín, Alicia
dc.date.accessioned2024-01-17T09:05:57Z
dc.date.available2024-01-17T09:05:57Z
dc.date.issued2008-04
dc.description2007 Elsevier B.V. All rights reserved. Financiación: AGL2004-08092 of the Spanish Ministry of Science; ParaTBTools (STREP 23106) of the European Union. Julio Álvarez: predoctoral grant assigned by the Spanish Ministry of Education and Culture.
dc.description.abstractDetection of infected animals is a key step in eradication programs of tuberculosis. Paratuberculosis infection has been demonstrated to compromise the specificity of the diagnostic tests. However, its effect on their sensitivity has not been clarified. In the present study, skin tests and the interferon-gamma (IFN-γ) assay were evaluated in a goat flock (n = 177) with a mixed tuberculosis–paratuberculosis infection in order to assess the possible effect of paratuberculosis on their sensitivity. Culture of mycobacteria was performed as the gold standard to determine the true infection status. All techniques showed lower sensitivities than previously described; the single intradermal tuberculin (SIT) test and the IFN-γ assay detected 71% (62.4–78.6, 95% C.I.) of the infected animals; the single intradermal cervical comparative tuberculin (SICCT) test detected only 42.7% (34.1–51.7, 95% C.I.) of infected animals. The highest level of sensitivity was obtained when SIT test and IFN-γ assay were combined in parallel (90.8%, 84.5–95.2, 95% C.I.). Sensitivities of the tests were also assessed by comparing animals suffering tuberculosis and animals with a mixed infection; tests were found to be more effective in the former group. Paratuberculosis seems to have a major effect in the sensitivity of the diagnostic tests under study, and therefore must be taken into account; in particular, the use of the SICCT test should be questioned when both tuberculosis and paratuberculosis are present.
dc.description.departmentDepto. de Sanidad Animal
dc.description.facultyFac. de Veterinaria
dc.description.facultyCentro de Vigilancia Sanitaria Veterinaria (VISAVET)
dc.description.refereedTRUE
dc.description.sponsorshipEuropean Union
dc.description.sponsorshipMinisterio de Ciencia y Tecnología
dc.description.sponsorshipMinisterio de Educación y Cultura
dc.description.statuspub
dc.identifier.citationAlvarez, J., de Juan, L., Bezos, J., Romero, B., Sáez, J. L., Reviriego Gordejo, F. J., Briones, V., Moreno, M. A., Mateos, A., Domínguez, L., & Aranaz, A. (2008). Interference of paratuberculosis with the diagnosis of tuberculosis in a goat flock with a natural mixed infection. Veterinary microbiology, 128(1-2), 72–80. https://doi.org/10.1016/j.vetmic.2007.08.034
dc.identifier.doi10.1016/j.vetmic.2007.08.034
dc.identifier.issn0378-1135
dc.identifier.officialurlhttps://www.sciencedirect.com/science/article/pii/S0378113507004488
dc.identifier.urihttps://hdl.handle.net/20.500.14352/93528
dc.issue.number1-2
dc.journal.titleVeterinary Microbiology
dc.language.isoeng
dc.page.final80
dc.page.initial72
dc.publisherELSEVIER SCI LTD
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu579
dc.subject.keywordTuberculosis
dc.subject.keywordParatuberculosis
dc.subject.keywordGoat
dc.subject.keywordSkin test
dc.subject.keywordSIT
dc.subject.keywordSICCT
dc.subject.keywordIFN-γ
dc.subject.keywordSensitivity
dc.subject.ucmMicrobiología (Veterinaria)
dc.subject.unesco3109.05 Microbiología
dc.titleInterference of paratuberculosis with the diagnosis of tuberculosis in a goat flock with a natural mixed infection
dc.typejournal article
dc.type.hasVersionAM
dc.volume.number128
dspace.entity.typePublication
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