Bioinspired extracellular vesicle-coated silica nanoparticles as selective delivery systems

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dc.contributor.authorDumontel, Bianca
dc.contributor.authorJiménez-Jiménez, Carla
dc.contributor.authorVallet Regí, María Dulce Nombre
dc.contributor.authorManzano García, Miguel
dc.date.accessioned2024-07-03T11:50:17Z
dc.date.available2024-07-03T11:50:17Z
dc.date.issued2023-12
dc.description.abstractIn recent years, there has been a breakthrough in the integration of artificial nanoplatforms with natural biomaterials for the development of more efficient drug delivery systems. The formulation of bioinspired nanosystems, combining the benefits of synthetic nanoparticles with the natural features of biological materials, provides an efficient strategy to improve nanoparticle circulation time, biocompatibility and specificity toward targeted tissues. Among others biological materials, extracellular vesicles (EVs), membranous structures secreted by many types of cells composed by a protein rich lipid bilayer, have shown a great potential as drug delivery systems themselves and in combination with artificial nanoparticles. The reason for such interest relays on their natural properties, such as overcoming several biological barriers or migration towards specific tissues. Here, we propose the use of mesoporous silica nanoparticles (MSNs) as efficient and versatile nanocarriers in combination with tumor derived extracellular vesicles (EVs) for the development of selective drug delivery systems. The hybrid nanosystems demonstrated selective cellular internalization in parent cells, indicating that the EV targeting capabilities were efficiently transferred to MSNs by the developed coating strategy. As a result, EVs-coated MSNs provided an enhanced and selective intracellular accumulation of doxorubicin and a specific cytotoxic activity against targeted cancer cells, revealing these hybrid nanosystems as promising candidates for the development of targeted treatments.
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.facultyFac. de Farmacia
dc.description.fundingtypeDescuento UCM
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia e Innovacion (España)
dc.description.sponsorshipEuropean Commission
dc.description.sponsorshipComunidad de Madrid
dc.description.statuspub
dc.identifier.citationBianca Dumontel, Carla Jiménez-Jiménez, María Vallet-Regí, Miguel Manzano, Bioinspired extracellular vesicle-coated silica nanoparticles as selective delivery systems, Materials Today Bio, Volume 23, 2023, 100850
dc.identifier.doi10.1016/j.mtbio.2023.100850
dc.identifier.issn2590-0064
dc.identifier.officialurlhttps://doi.org/10.1016/j.mtbio.2023.100850
dc.identifier.relatedurlhttps://www.sciencedirect.com/science/article/pii/S2590006423003101#section-cited-by
dc.identifier.urihttps://hdl.handle.net/20.500.14352/105549
dc.journal.titleMaterials Today Bio
dc.language.isoeng
dc.publisherElsevier
dc.relation.projectIDPR47/21-MAD2D-CM
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106436RB-I00/ES/NANOPARTICULAS INTELIGENTES PARA EL HUESO OSTEOPOROTICO/
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC//694160
dc.relation.projectIDPR38/21-21
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu615:54
dc.subject.keywordNanoparticles
dc.subject.keywordExtracellular vesicles
dc.subject.keywordBioinspired nanocarriers
dc.subject.keywordSelective targeting
dc.subject.ucmCiencias Biomédicas
dc.subject.ucmFarmacia
dc.subject.ucmQuímica farmaceútica
dc.subject.unesco2390 Química Farmacéutica
dc.titleBioinspired extracellular vesicle-coated silica nanoparticles as selective delivery systems
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number23
dspace.entity.typePublication
relation.isAuthorOfPublication78c9fb3f-bd15-4c15-bff0-e1f83e0df99f
relation.isAuthorOfPublication791023b8-2531-44eb-ba01-56e3b7caa0cb
relation.isAuthorOfPublication2a7febe9-6dd2-4117-aa12-552e54c12bd3
relation.isAuthorOfPublication.latestForDiscovery78c9fb3f-bd15-4c15-bff0-e1f83e0df99f
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